Imipramine

Question 1

what is Imipramine

Answer 1

Catecholamine uptake inhibitor

tricyclic antidepressant

Question 2

mechanism of action of Imipramine

Answer 2

The mechanism of action of Imipramine is via inhibiting the sodium-dependent serotonin transporter and sodium-dependent norepinephrine transporter preventing or reducing the reuptake of norepinephrine and serotonin by nerve cells.

Question 3

what is the slowing of the uptake of these NT thought to contribute to

Answer 3

relieving symptoms of depression.

Question 4

how does Imipramine lead to enhanced serotonergic transmission

Answer 4

causes down-regulation of cerebral cortical b-adrenergic receptors and sensitization of post-synaptic serotonergic receptors with chronic use

Question 5

how long does it take for the antidepresssant effects of imipramine to happen?

Answer 5

It takes approximately 2 - 4 weeks for antidepressants effects to occur but can be up to 8 weeks.