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Endocrine > thyroid disease > Flashcards

thyroid disease Flashcards

1
Q

symptons of hypothyroidism

A

lathargy, cold intoleergy, weight gain, non spefici weakness, artraolai, constipation, menstration irregularities, depression, impared contention, dry skin, reduced body pair, thyroid pain

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2
Q

signs of hypothyroidsm

A

corase dry har/ skin
oedema including swelling of eyelids
vocal changes - horaseness
goitre
bradycardia
delayed relaxation of deep tendon relfexe
paraesthisa

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3
Q

blood tests for hypothryoids

A

fbc, glucose or hba1c

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4
Q

what are signs of hyperfthosm

A

weight loss
anxiety/ irrabilty
heat intolenv
bowel frequency
light periods
seweaty palms
palitations
byperrelexia
goitre
thryoid eye symtposn

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5
Q

causes of hypothryoidsm congential

A
  • developmental through ageness adn nmaldevelopement
    dysphomogneises - trapping / orgnificaiton
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6
Q

causex of acuired piamry hypotharims

A

automimmune thryoid diseae - hashimotos
latrogentic - thorug posto oprative, post radioacite antithroid drugs,
iodein insupifceiy
post sub acute thryoiditsi

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7
Q

drugs which can cuase hypothrosidm

A

amiodarne, lithum interferon

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8
Q

cause of secondary and terpty hpothm

A

tumrou of pituary
crainophaygioma
post pituary surgeyr or radiotherapy

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9
Q

dyshormonegitsi

A

inabilty to to loss of certian thryoid enzymes to produce thryoid hormens

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10
Q

agenesisi

A

loss of developmen of some organs during feotal growth

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11
Q

what is hashimotos

A

autoimmune inflammation of the thryoid gland preventing it from functioning effectively

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12
Q

tests for hasmitoms

A

thyroid peroxidaes autoantimbies
anti thryoglobulin antibodies

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13
Q

treatment for hypothryodism

A

if under 65 and no cardiac disase - 1.5 micro grams per kg of levothyroxine
if over65 or have cardiac disae - 25 - 50 mcg daily of levothyroxine

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14
Q

when shoudl levothryoxine be taken

A

first thing in the morning on an emzypty suomach , or it can be last thing at night after 2 house since meal

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15
Q

what is sublicla hypothyodism

A

raised tsh, but noral t3 and t4

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16
Q

when should you treat sublcinal hypothyaism

A

if the blood are stial deraned after 3 months, they are less than 65 and they have symptoms of hypothrysism

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17
Q

clicnal treatment for subcliam hypotgrysm

A

6 motnn trial of levothryoxine and see if there is reduction in symptoms

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18
Q

when should monitoring be for subclicnal hypothrysom

A

anual tfts - if you have postive thyroid peroxidase antibois, had thyroid surgery underlying thryid disease
every 2-3 years if negative thryoid peroxidaes antibodis

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19
Q

how should thryoid medication be changed in pregnacny

A

add preconcentin replacemtn of less than 2.5ul
add an empirical dose depending on thyroid hormone level
regular monitoring in pregnancy
aim for tsh inolower noamrl range
reduce levothryoixin after birth
recheck after 2 - 3 montsh

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20
Q

risk for overtramen of hypothrimdism

A

osteopenai, fracture, afib

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21
Q

differnece betwen hyperthryidsm and thryoxicois

A

hyperthrydism is just the excess production of thyroid hormones by the thyroid gland
thryoxididoxi is the production fo excess thryodi hormes by the thyroid gland or another sources such as gravesq

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22
Q

causes of praimary thryoditoxici

A

graves
toxic multinodular goitre
toxic adenoma

23
Q

cuase of seconary thryodtoicis

A

pituatry adneoma sectring tsh

24
Q

cause of thyrotoxicio with hyperthrisms

A

destructive thryodistis - often post partum
excessive thryoxine administaion

25
Q

causes of graves disease

A

either thryoid peroxisease antiboids or tsh recpeot antibiidse

26
Q

signs of graves

A

buling eyes due to perioriabl swelling - Exophthalmos
rahses -Pretibial myxoedema
goitre
clubbing

27
Q

what does multindoul goitre look like

A

lots of differ goitre in neck

28
Q

who does mulinootu goture maily effect

A

elderly

29
Q

waht is dequivains throdisis

A

flu like thryodi swelling that last for a few weeks, cuases hyperthrosism as well

30
Q

mangemnet of thryoditis

A

beta blockr

antithrydoi drugs
iodine and suergy

31
Q

example of antithyid drugs

A

carbimazole and propylthiouracil

32
Q

side effects of antithryoid drugs

A

rash, agranulocytois

33
Q

effectivens of antithryoid dugs vs radioaid

A

radioioden 90% cure
atd - 40% cure

34
Q

what other drug help stop protodsjm

A

steroids

35
Q

should you stop atd berofre raidoidone

A

yes - 4 days before and after

36
Q

phsyolicl cuase of goitre

A

puberty
pregnacy

37
Q

autimmine cuase of goitre

A

gravs and hasimotos disease

38
Q

thryoidits cuase of gotre

A

acure - dequviarns
chronic fiberioti ce.. reildesl

39
Q

tumore of goiture

A

adenoma, carcinoma, lymphoa

40
Q

miscall tymesp f girtre

A

sarcodiois and tb

41
Q

what is the chagne of a solidary noule on thryid is malignat

A

5%

42
Q

how to infesitge solidatyr nodule

A

thryoid fucntion test
ultrasound - to deterinn binign / malignatn

43
Q

what is ultrasound is potive for thryoid cancer malifty

A

fine neelde aspiration

44
Q

thy1 , thy 2 and thy5 reuslts form fine needle aspiration

A

thy1 inadequate
thy2 - benign
thy 5 - cancer

45
Q

most common type of differnation thryoid cclcner

A

papilliary -

46
Q

other type so fthyri differtiaed cner

A

follicular

47
Q

treatment fo throid cncer

A

thryoidencotm
high dose radioiione
logn term suppreiosn of thryoxine

48
Q

follow up for thryoid cncer

A

whole bondy iodien scan after 2 wekks of thryoixne withdrawal
tg and neck lutrosund
thryoglobulin

49
Q

proglnos of anaplaic trhyoid ccaner

A

very poor

50
Q

cause of lymphoa thryoid cacner

A

often hasimoots hyrodisits

51
Q

what is medullayr thryoid cancer assoiced with

A

hyperparthryoidsm an phaeochromatya

52
Q

signs of meucllary thryoid cncaer

A

raised serum clcionin levles

53
Q

treatment for meullar thryoid cncer

A

totla thryidoecty

54
Q
A

Endocrine (20 decks)

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