thyroid disease Flashcards
symptons of hypothyroidism
lathargy, cold intoleergy, weight gain, non spefici weakness, artraolai, constipation, menstration irregularities, depression, impared contention, dry skin, reduced body pair, thyroid pain
signs of hypothyroidsm
corase dry har/ skin
oedema including swelling of eyelids
vocal changes - horaseness
goitre
bradycardia
delayed relaxation of deep tendon relfexe
paraesthisa
blood tests for hypothryoids
fbc, glucose or hba1c
what are signs of hyperfthosm
weight loss
anxiety/ irrabilty
heat intolenv
bowel frequency
light periods
seweaty palms
palitations
byperrelexia
goitre
thryoid eye symtposn
causes of hypothryoidsm congential
- developmental through ageness adn nmaldevelopement
dysphomogneises - trapping / orgnificaiton
causex of acuired piamry hypotharims
automimmune thryoid diseae - hashimotos
latrogentic - thorug posto oprative, post radioacite antithroid drugs,
iodein insupifceiy
post sub acute thryoiditsi
drugs which can cuase hypothrosidm
amiodarne, lithum interferon
cause of secondary and terpty hpothm
tumrou of pituary
crainophaygioma
post pituary surgeyr or radiotherapy
dyshormonegitsi
inabilty to to loss of certian thryoid enzymes to produce thryoid hormens
agenesisi
loss of developmen of some organs during feotal growth
what is hashimotos
autoimmune inflammation of the thryoid gland preventing it from functioning effectively
tests for hasmitoms
thyroid peroxidaes autoantimbies
anti thryoglobulin antibodies
treatment for hypothryodism
if under 65 and no cardiac disase - 1.5 micro grams per kg of levothyroxine
if over65 or have cardiac disae - 25 - 50 mcg daily of levothyroxine
when shoudl levothryoxine be taken
first thing in the morning on an emzypty suomach , or it can be last thing at night after 2 house since meal
what is sublicla hypothyodism
raised tsh, but noral t3 and t4
when should you treat sublcinal hypothyaism
if the blood are stial deraned after 3 months, they are less than 65 and they have symptoms of hypothrysism
clicnal treatment for subcliam hypotgrysm
6 motnn trial of levothryoxine and see if there is reduction in symptoms
when should monitoring be for subclicnal hypothrysom
anual tfts - if you have postive thyroid peroxidase antibois, had thyroid surgery underlying thryid disease
every 2-3 years if negative thryoid peroxidaes antibodis
how should thryoid medication be changed in pregnacny
add preconcentin replacemtn of less than 2.5ul
add an empirical dose depending on thyroid hormone level
regular monitoring in pregnancy
aim for tsh inolower noamrl range
reduce levothryoixin after birth
recheck after 2 - 3 montsh
risk for overtramen of hypothrimdism
osteopenai, fracture, afib
differnece betwen hyperthryidsm and thryoxicois
hyperthrydism is just the excess production of thyroid hormones by the thyroid gland
thryoxididoxi is the production fo excess thryodi hormes by the thyroid gland or another sources such as gravesq
causes of praimary thryoditoxici
graves
toxic multinodular goitre
toxic adenoma
cuase of seconary thryodtoicis
pituatry adneoma sectring tsh
cause of thyrotoxicio with hyperthrisms
destructive thryodistis - often post partum
excessive thryoxine administaion
causes of graves disease
either thryoid peroxisease antiboids or tsh recpeot antibiidse
signs of graves
buling eyes due to perioriabl swelling - Exophthalmos
rahses -Pretibial myxoedema
goitre
clubbing
what does multindoul goitre look like
lots of differ goitre in neck
who does mulinootu goture maily effect
elderly
waht is dequivains throdisis
flu like thryodi swelling that last for a few weeks, cuases hyperthrosism as well
mangemnet of thryoditis
beta blockr
antithrydoi drugs
iodine and suergy
example of antithyid drugs
carbimazole and propylthiouracil
side effects of antithryoid drugs
rash, agranulocytois
effectivens of antithryoid dugs vs radioaid
radioioden 90% cure
atd - 40% cure
what other drug help stop protodsjm
steroids
should you stop atd berofre raidoidone
yes - 4 days before and after
phsyolicl cuase of goitre
puberty
pregnacy
autimmine cuase of goitre
gravs and hasimotos disease
thryoidits cuase of gotre
acure - dequviarns
chronic fiberioti ce.. reildesl
tumore of goiture
adenoma, carcinoma, lymphoa
miscall tymesp f girtre
sarcodiois and tb
what is the chagne of a solidary noule on thryid is malignat
5%
how to infesitge solidatyr nodule
thryoid fucntion test
ultrasound - to deterinn binign / malignatn
what is ultrasound is potive for thryoid cancer malifty
fine neelde aspiration
thy1 , thy 2 and thy5 reuslts form fine needle aspiration
thy1 inadequate
thy2 - benign
thy 5 - cancer
most common type of differnation thryoid cclcner
papilliary -
other type so fthyri differtiaed cner
follicular
treatment fo throid cncer
thryoidencotm
high dose radioiione
logn term suppreiosn of thryoxine
follow up for thryoid cncer
whole bondy iodien scan after 2 wekks of thryoixne withdrawal
tg and neck lutrosund
thryoglobulin
proglnos of anaplaic trhyoid ccaner
very poor
cause of lymphoa thryoid cacner
often hasimoots hyrodisits
what is medullayr thryoid cancer assoiced with
hyperparthryoidsm an phaeochromatya
signs of meucllary thryoid cncaer
raised serum clcionin levles
treatment for meullar thryoid cncer
totla thryidoecty
