Pituatary diseease Flashcards
what is hyper sectino of gh
acromeglay or gigantism if before epitpseal plates seal
what is hypersection of acth
cushings
what is hypersection of prolactin
hyperprolactinemae
what is hyposection of main cause
tumoru in pitutaary
what are teh soft tissues overgrowth signs of acromegaly
spade like hands
wide feet
coarse facial features
thick lips and tounge
carpal tunnel syndome
sweatting
complacation of acromegaly
headach, chiasmal compression, diabetes mellitus, hypertieon
cardiomyotphy
sleepapnes
colon polyps
how si teh diagnoss of acromglay made
gh - and if it can be supersed by insulin- through inclrus glucose
vision changes
igf 1 as it has a longer half life than gh
mri for pituatar ademnoa
acromelgy
hyposection of gh from anteiroer pituatary
type of cacner of acromeglay
pitutary adenoma
non pituary cause of acromeglay
other cancers such as lung or pancreastic stimuar gsrh
treatment for acromegaly surgery
removal of pituary tumour through trans spenoid surgery
radiothary
hormones to stop growth of tumour
medical treatment ofr acromegaly
Pegvisomant is a growth hormone receptor antagonist given daily by a subcutaneous injection
Somatostatin analogues (e.g., octreotide) block growth hormone release
Dopamine agonists (e.g., bromocriptine) block growth hormone release
cause of cushing
excess cortisol
effet of cushings
tissue breakdown,, sodium retieion inuslin antagonism (diabetes)
signs of cushigh
skin atrpoy
spontaneous purpura
proxial myopthy
osteoproriss
growth arrest in childrne
pink striea
facila mooning
odema
achtm dependt cushing syndome
pittuar tumoru - cushings disease
ecotpic acht section form lung cancer
acth indepent cushings
adrenal tumoure
corticosterid treatmetn
causes of hyperproalciam
pregnancy, laction and stress
pharmalogical - da depleting and da antagonist
pathological 0 primary hypothyroidsm , pituatary lesions
symptons of hyperprolacinemae in women
galactorrhoea
menstural irregulatiry
inferitly
symptoms of hyperprolactinaemia in men
galactorrhoea, impotence, visual field abnormalities , headache, extraocular muscle weakness, anterior pituitary malfunction
drugs that cuase hyperprolaciname
da depleting agents
dopamine antagois - neuroleptics, antiemetics
osetrogen
some antidepressants
clincal features in adults of hypopituitarism
tiredness, weight gain, depresssion, reduced libo, impotenece, menstration probel, skin pallar, reduced body hair
clicnal fearut of hypotitipicm children
reduced linar growth, delayed puberty
effet of acp water deperation test
depreve wtaett for peroid of tiem , then gi e sympth adh to shwo that it is a probel with low adh
causes of diabetes inspitus
lack of ach or lack of respose to adh
what type of diabetes inspitu is lack of adh
central
what type of diabetes inspiitus is lack of respone to adh
neprogenic
Polyuria
excessive ammont of urine
Polydipsia
excessive thrist
what is sympootns of diabets inspigptus
polydispia and polyruia
what is priamry polydispia
due to the paiten dirinkin too much water and not due to diabetes
cause of central diabets inspipitus
Brain tumours
Brain injury
Brain surgery
Brain infections (e.g., meningitis or encephalitis)
Genetic mutations in the ADH gene (autosomal dominant inheritance)
Wolfram syndrome (a genetic condition also causing optic atrophy, deafness and diabetes mellitus)
cuase of peripharl diabetse insipidus
Medications, particularly lithium (used in bipolar affective disorder)
Genetic mutations in the ADH receptor gene (X-linked recessive inheritance)
Hypercalcaemia (high calcium)
Hypokalaemia (low potassium)
Kidney diseases (e.g., polycystic kidney disease)
effect of piamry polydispa on water withdra
will casue urien osmoarl to be high thus adh will not need to be given
effect of stomaot stain analgine ia cacmeo
impoef sties oergowth , sleep apena
fix gh and igf levles
cuase brain tumou to shrink
adverse effects of stoamtostopin analge
nausea, cramps, dirrhoea, flatulence, cholestol gallstones, slow relase peperation with montly im/sc injection
what are example somatostatin
octreotide
lanreotide
what is exajme of modifed analag gorwth hormone
pegvisomant
what is micropolacioma
where the pituar gland is les than 10 but cuase prolaciaom side effects
treatmetn for micorpolaioma
dopamien agonisits e.g. cabergoline
treatmetn of macropolactinoma
dopamine agoniss
time to treat prolacinoma with dopane agaos
normally a few days
