3 - Contorl of metabolism (part 2) Flashcards

1
Q

effect of increase glucogon

A

increase glycogenlysiss
increaeds gluconegeneisis
increasek ketogenteies

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2
Q

where is glucgon reaolsed form

A

alpha pancretic islet cells

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3
Q

where is glucgon degraradd form

A

liver

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4
Q

what is the action of glucagon

A

opposes insulin

increases glycogenolsys
incrrease gluconegoenseis (break down of aa and glycerol from fat)
formation of ketones from fa ( fat)

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5
Q

where if the fatty acids realsed from in decreased blood clules

A

mucle and adipose tissue

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6
Q

effect of amino acids on glucagon

A

causes release of glucagon secretion

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7
Q

what would happen if there was no glucagon realsed when aa amino acids are activaed

A

only insulin would be realsed , tus would drastically lower blood sugar, causing catastrophic effects in the brain

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8
Q

why does amino acids stimulate both insulin and glucagon

A

as aa effect to lower blood glucouse, thus bg would lower to a dangerously low level

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9
Q

what stimuli promote glucagon release

A

low bg
high amino acid
sympathetic inervationa nd epeipeglie
cortisol
stress

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10
Q

what stimuli inhibit glucagon relase release

A

glucose
ffa
insulin
somatostatin

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11
Q

effect of vaugs on glucagon

A

increase the release of it, in a pre exittaory state

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12
Q

sympathic effect on insulin

A

inhibitory

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13
Q

what is the function of stomaotsttain

A

inhibits absoption and activity of gi tract
it also suppresses release of insulin and glucagon in pancreas

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14
Q

what is the effect of a somatostain secreting pancreatic tumjour

A

have symotoms of diabees as low blood insulin and glugaon

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15
Q

whihc moclues can do proeitn catabolsim ( breakdown

A

cortisol

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16
Q

effect of growth hormon

A

gluconeogeniss, inhibits glucose uptake, lipolysis

17
Q

effect of epineprhine

A

muscle glycogenolsys, liver glycogenolysis, gluconeogesis, lipolysis

18
Q

does glucogon cuaisn increase or decreaes blood glucose

A

increase

19
Q

does insulin cuase an increas or decrease in blood glucose

A

decrease

20
Q

effect of entry of glucose in exerise in musles

A

glut 4 migrate to teh surface with out the ned for insulin

21
Q

how does the sensity of muces change to insulin as you exercise more

A

increase sensitivity to insulin

22
Q

how does the brain change after a period of starvation

A

it gest use to the increase ammount of ketones and can adapt to be more sensitive to them

23
Q

what is used as an ergery souc e during starvation

A

adipose tisue, which convert to ffa, which convert to ketone bodies

24
Q

what is the last store to be broken down in infection

A

protein

25
Q

what is type 1 diabests

A

auto immue distruction of pancreatic b cells, produce insulin, 10 % are insulin dependent as they cannot absobr insulin form plasama

26
Q

effect of liver in diabeests

A

liver still produces gluces due to not effect of insulin, thus further increase blood glcueos

27
Q

what is ketoacidiods in t1d

A

when nutoreia are scare, body releis on ffa and ketones body for mucel and brain, howere when inulin diabets is poorly controlled, a lack of inulin depresses ketone body uptake, building it up rapidly in plamas and create a life threating alkyalsids, needing treating with hours

28
Q

what is t2d

A

where the periphearl tissues beocme insulin resistance

29
Q

what is teh tests for insulin reistance

A

glucose tolerence tests

30
Q

how is a gluceo tolerance tests done

A

increa the glucose and measre the repsone after 1 hour and 2 hour comparent dot a normal patient

31
Q

how to converted mg/dl to mm

A

dived mg/dl by 18

32
Q

effects of long term hyperglycemia

A

retinopathy
neuropathy
nephropathy
cvd