Pathology of endocrine disease Flashcards

1
Q

what does a adenohypophhysis secret

A

acth, tsh, gh, prolatin and fsh, oh

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2
Q

wher is an adenohypophs found

A

in the antiero pituary

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3
Q

where is a neurohyposthso found

A

in th epostuor pituary

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4
Q

how doe a neurohypos form

A

down growht of the postioer pituratyr

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5
Q

what does a neurohyposys sectre

A

adh, oxytocin

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6
Q

most common cause of pituatyr hyerfuiton

A

pituary adenaom

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7
Q

what is the cuase of pituar doem

A

MOST OCMLY SPORATID BUT CNA BE ASSOCATED WITH MEN 1 GENE

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8
Q

effect of pituary adenaom

A

if fuciton - will cuas hormen exess e.g. galactorreha, menaution disor if prolaio
gh seciton - acromely
acth - cugiongs
non fucniton - can cuase viusl fil aboma nd raised icp

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9
Q

cause of pituary hypofuction

A

compression by tumor such as craniophyngioma
tramua
infectino - such as tb adnd sarcoidso

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10
Q

grave disase cuase

A

anti tsh recort antiboids

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11
Q

cause of hypo thyodism

A

hashiomos
lartorngei
iodine defin
congeital

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12
Q

types of thyrodi gand cancer

A

follicular adneoama
caronma - makes up 5% of cancers
- papllary - 75%
Folliucaor - 10%
medullary / lymphoa - 5%
anaplatic 5%

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13
Q

what is papilary cariona assoiced with

A

braf muation and ionzing radiation

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14
Q

what is medullar carcinoma assoicaed with

A

mend 2a, men2b, famialry fmtc

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15
Q

treatment for thyrodi cancoma

A

surgery, radioactive iodine, external raidothery, chemotharym

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16
Q

case of parathryod hyperfion

A

sporad or famialy men 1
- adneoma - 90%
hyperplaia - 5-10%
decreas response to ca 2+ renal cncer

17
Q

effect of men1 / wermer syneom

A

parathryoid hyperlais and adenoa
pancreatic duodenal endocrine tumour
pituitary adnoma - prolacinaoma

18
Q

efffect of men 2 gne mutioan

A

medullar cariom of thryoid
phaeochrocytoma

19
Q

effect of men 2a

A

parathryoid hyprlaisa

20
Q

effect of men 2b

A

neuromas of skin and mucos membrane, skelat aboma, phenocymoaas

21
Q

what pathy is men 2b

A

tyrosien kinase

22
Q

what pathway is men 2a

A

ret recpor auto dimeriaion

23
Q
A