Adreanl gland disoders Flashcards

1
Q

source of aldostoer

A

minearl cortocisoid

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2
Q

source of cotisol

A

glucocorticoids

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3
Q

scoure of teostostore

A

sex tsroids

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4
Q

medulla rodues

A

norepinephrine, epinephrine

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5
Q

what is te hypalmo hypotpiaau adranl axis

A

determes thorugh negative feed bakc how much crh and acth relses is needed to prused cortsol form adrenal glands

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6
Q

what is the funciton of 21 hydrolase

A

allows coverstio of coldseot to aldosertone and corlisol

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7
Q

effect on skin in lack of 21 hydrolzase

A

hyperpginat, increas skin oildness

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8
Q

which zona is mineracol coricoid form

A

glomerulosa

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9
Q

which zona is glucocoritostoier form

A

fasiculata

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10
Q

which zona is sex steorid from

A

reticularis

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11
Q

name of hypofunction adrnal disorder

A

addisons

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12
Q

causes of addison

A

autommine (85%)
infection e.g hiv and tb
metatisc
loss of 21 hydroxlase deficit

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13
Q

antiboid of addision

A

21 ohase aut antiboidswe

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14
Q

what othr disease are assoicated with adidisons

A

type 1 diabets
thryoid
ovarian faiulre

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15
Q

main symptnos of addison

A

weakness, fatique, weight loss, salt crain, hperpigmation, hpo teion, vomiting, or dirrhea, postural sympotns

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16
Q

signs of adranl ciris

A

collapse, hpotesoin, severe dehydaiton

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17
Q

what corisol lsev indiactes addision

A

less than 450 nmol

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18
Q

tests for addions

A

synacthem stess and basl acth

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19
Q

synacthme tests

A

give acth ot a paite and if there si n person it is primary and if her is limited repsoen compare t normal it is secondary

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20
Q

how to test difference between primary and secaty acth

A

if plam leve elated primary
suppresed secondary

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21
Q

test for addinos if adfnral antibod negative in males

A

vlcfa - fatty caid ahisn which could be due to body not being able to break down certain fats
adrnal imaging

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22
Q

first screeing fo cuase of pirary hpothism

A

auteim immuen antibodies

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23
Q

what is the dose of glucocortiocds repalse

A

hydrocoritsx, prensol and dexmeation, hc both in morign and at night

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24
Q

does of mineral cortiocd replacement

A

mineral croicod wihc bind to fludrocorosen

25
what to do if you have minor hort illens with addions
double dose of glucocofoid
26
what to do if you hav ea major operations
times 5 times ammoutn f hydorcoids hydorocd at srtart of operaiton
27
what to do if you have sever vommitn or diarrhe for hydrocoise
get im injection
28
endocrien caue of hypertension
prmary hyperaldoser, adenoma, bilaterla hyperlaia, phaemochromcytoma, cushing, acromegaly, hyperparathryoism, hpotharyism, congetical adral hyprelaisa
29
what is cushign sydnoem
hperseciotn of cortios,l, androgens,
30
cause of cushing
adenoam, bilatarl hyperlai, carinma
31
what is cons
exces section of aldosteorn
32
cause of conns
adenoam or bilaterl hyperlsi
33
what is phaemochromocytoma
excess catecholamiesn
34
effect of cusign
tissue break down, soudm retion, inusling antagoism resuing in diabets mellitus, easly bruing, purple striae, hirrusim, glucose intolese, hyperion, central obeitsy
35
cause of atch depenet cuign
exptoic acth seciton form lugn cnacer pituatry turmou
36
cause of acth indepoin cuign
adrnal tumour
37
approach to hyperconriticolism
over nihg dex test, low dose dext test, acth coriosl test, high dose dex test, mri to fi find site of lesion
38
treatment of cugins
surgery to remove turmour adrenal horme synthes inhibtorps and destro adrenal cortioc cells raiothary adrenalectomy
39
drugs that act as adrnal horme syntheis inhibtors
ketoconzole metyrapone aminoglutethimide etomidate
40
drugs that destoryadrnaocorciodi cells
mitane
41
what cauese tothe reosi of aldoser
renign dueto decreaedd renal perfusion
42
what produced ace
surface f pulamr and renal epithm
43
effect of aldosteron
relsease of k+ and reabsobtion of h30 and na
44
screing for conns
plama aldosor to plama renin activity ratio wehre over 20 primary hyperaldosteronsim under 20 seconary hyperp aldoseronsim
45
conficotn of cons test
24 hr undar aldoserene and solumidum during r4 days of salt loaing then ct of adnral gland and plasma 18 hydroxycloriosen
46
effect of k and na in conns
increa na and decreaed k due to los of k in incre
47
symponf of phaemochromytoma
hypertin, headjac, swelling , palpion, tremour, pallor anxiety
48
10% meaning in phenochomcytoma
10% extra adrnal 10% malignat 10% mulik 10% hyperglycmae
49
inherited gens of phaemochromytoma
30% are inhered incluig men 2
50
what does men 2 cause
phaneocytoma meullar thryoid cance parathryoidm adneoma
51
effect of von hoppel landau syndome
phaechromocytoma cerebral and retinal angiomatosis pancreatic and renal cysts epidydymal cystadenomas
52
conseeques of men 2b
phaechromocytoma medullary thryoid cancer mucocutanous syndormes multiple nuronam marfanoid habitus hypertrophied corneal nerves
53
how to diagentos phenocorm sycmoa
if low supser 24 hour urine of metanephriies if high spigh 24 of catecholamines, total metephies and plamametophies
54
what to do if raised metaphoes
locasied tumoru with mri / ct in adral or aoidal area
55
what scna after mri for phenochromcytoa
123 i mibg scan
56
treatmet for phamocyyma
surgical restion alpha adrenogic blockade b blocker ccb ace inhibotrs
57
what to do for endocrine mass
full endocine work up incluig free metenphein in plama dextametose supreion test potatium and ald pra ration, if secreting horme surgyer if not secting hormone - ct scan and image after 6 - 12 month with endo cirne evalre every year for 4 years
58