Adreanl gland disoders Flashcards
source of aldostoer
minearl cortocisoid
source of cotisol
glucocorticoids
scoure of teostostore
sex tsroids
medulla rodues
norepinephrine, epinephrine
what is te hypalmo hypotpiaau adranl axis
determes thorugh negative feed bakc how much crh and acth relses is needed to prused cortsol form adrenal glands
what is the funciton of 21 hydrolase
allows coverstio of coldseot to aldosertone and corlisol
effect on skin in lack of 21 hydrolzase
hyperpginat, increas skin oildness
which zona is mineracol coricoid form
glomerulosa
which zona is glucocoritostoier form
fasiculata
which zona is sex steorid from
reticularis
name of hypofunction adrnal disorder
addisons
causes of addison
autommine (85%)
infection e.g hiv and tb
metatisc
loss of 21 hydroxlase deficit
antiboid of addision
21 ohase aut antiboidswe
what othr disease are assoicated with adidisons
type 1 diabets
thryoid
ovarian faiulre
main symptnos of addison
weakness, fatique, weight loss, salt crain, hperpigmation, hpo teion, vomiting, or dirrhea, postural sympotns
signs of adranl ciris
collapse, hpotesoin, severe dehydaiton
what corisol lsev indiactes addision
less than 450 nmol
tests for addions
synacthem stess and basl acth
synacthme tests
give acth ot a paite and if there si n person it is primary and if her is limited repsoen compare t normal it is secondary
how to test difference between primary and secaty acth
if plam leve elated primary
suppresed secondary
test for addinos if adfnral antibod negative in males
vlcfa - fatty caid ahisn which could be due to body not being able to break down certain fats
adrnal imaging
first screeing fo cuase of pirary hpothism
auteim immuen antibodies
what is the dose of glucocortiocds repalse
hydrocoritsx, prensol and dexmeation, hc both in morign and at night
does of mineral cortiocd replacement
mineral croicod wihc bind to fludrocorosen
what to do if you have minor hort illens with addions
double dose of glucocofoid
what to do if you hav ea major operations
times 5 times ammoutn f hydorcoids
hydorocd at srtart of operaiton
what to do if you have sever vommitn or diarrhe for hydrocoise
get im injection
endocrien caue of hypertension
prmary hyperaldoser, adenoma, bilaterla hyperlaia, phaemochromcytoma, cushing, acromegaly, hyperparathryoism, hpotharyism, congetical adral hyprelaisa
what is cushign sydnoem
hperseciotn of cortios,l, androgens,
cause of cushing
adenoam, bilatarl hyperlai, carinma
what is cons
exces section of aldosteorn
cause of conns
adenoam or bilaterl hyperlsi
what is phaemochromocytoma
excess catecholamiesn
effect of cusign
tissue break down, soudm retion, inusling antagoism resuing in diabets mellitus, easly bruing, purple striae, hirrusim, glucose intolese, hyperion, central obeitsy
cause of atch depenet cuign
exptoic acth seciton form lugn cnacer
pituatry turmou
cause of acth indepoin cuign
adrnal tumour
approach to hyperconriticolism
over nihg dex test, low dose dext test, acth coriosl test, high dose dex test, mri to fi find site of lesion
treatment of cugins
surgery to remove turmour
adrenal horme synthes inhibtorps and destro adrenal cortioc cells
raiothary
adrenalectomy
drugs that act as adrnal horme syntheis inhibtors
ketoconzole
metyrapone
aminoglutethimide
etomidate
drugs that destoryadrnaocorciodi cells
mitane
what cauese tothe reosi of aldoser
renign dueto decreaedd renal perfusion
what produced ace
surface f pulamr and renal epithm
effect of aldosteron
relsease of k+ and reabsobtion of h30 and na
screing for conns
plama aldosor to plama renin activity ratio
wehre over 20 primary hyperaldosteronsim
under 20 seconary hyperp aldoseronsim
conficotn of cons test
24 hr undar aldoserene and solumidum during r4 days of salt loaing
then ct of adnral gland and plasma 18 hydroxycloriosen
effect of k and na in conns
increa na and decreaed k due to los of k in incre
symponf of phaemochromytoma
hypertin, headjac, swelling , palpion, tremour, pallor anxiety
10% meaning in phenochomcytoma
10% extra adrnal
10% malignat
10% mulik
10% hyperglycmae
inherited gens of phaemochromytoma
30% are inhered incluig men 2
what does men 2 cause
phaneocytoma
meullar thryoid cance
parathryoidm adneoma
effect of von hoppel landau syndome
phaechromocytoma
cerebral and retinal angiomatosis
pancreatic and renal cysts
epidydymal cystadenomas
conseeques of men 2b
phaechromocytoma
medullary thryoid cancer
mucocutanous syndormes
multiple nuronam
marfanoid habitus
hypertrophied corneal nerves
how to diagentos phenocorm sycmoa
if low supser 24 hour urine of metanephriies
if high spigh 24 of catecholamines, total metephies and plamametophies
what to do if raised metaphoes
locasied tumoru with mri / ct in adral or aoidal area
what scna after mri for phenochromcytoa
123 i mibg scan
treatmet for phamocyyma
surgical restion
alpha adrenogic blockade
b blocker
ccb
ace inhibotrs
what to do for endocrine mass
full endocine work up incluig free metenphein in plama
dextametose supreion test
potatium and ald pra ration, if secreting horme surgyer
if not secting hormone - ct scan and image after 6 - 12 month with endo cirne evalre every year for 4 years
