Thyroid

Question 1

T3 vs T4

Answer 1

t3 is the active form, T4 turns into T3

Question 2

levothyroxine method of action

Answer 2

sythentic t4

Question 3

armor thyroid method of action

Answer 3

dry animal thyroid T3 and T4 that closely mimics human function

Question 4

anti thyroid products (methimazole) method of action

Answer 4

inhibits t3 and t4 production

Question 5

what do we use to gauge the effectiveness of the drugs

Answer 5

TSH
increase TSH: decrease Thyroid hormones
decreased TSH: increase thyroid hormones

Question 6

what do we need to monitor with methimazole

Answer 6

CBC and liver enzymes

Question 7

main side effects and key points of levothyroxine

Answer 7

chelation (do not take with food)
long half life
brand and generic are not the same

Question 8

main side effects and key points of methimazole

Answer 8

not a long term treatment
agranulocytosis
liver failure
used as a bridge treatment

Question 9

methimazole

Answer 9

hyper

Question 10

thyroid armor

Answer 10

hypo

Question 11

levothyroxine

Answer 11

hypo

Question 12

generic vs brand

Answer 12

brand you need to prove effectiveness and safety with your patent that lasts 12 years, you need to complete research which lasts 8-10 years, this is why brand names are more expensive because they are trying to make revenue in a short time

to make a generic you need to prove bio equality which requires less time and less research and less money

controversy: pharmacies will order the cheapest generic and the generics can vary 80-120% from the brand so your weekly dose will be a different percent and since the half life is so long there is no way of fine tuning the drug percent in body