Anti Nausea/Vomiting Flashcards
1
Q
what is CTZ
A
part of the brain stem that has been receptors and is not protected by BBB
2
Q
NV that can be prevented by 5-HT3 antagonists
A
post op, pregnancy, migraine, chemo, illness
3
Q
how do 5-HT3 antagonists work
A
prevent serotonin from stimulating the CTZ
4
Q
5-HT3 main side effects
A
QT prolongation= new arrhythmia
constipation
headache
5
Q
drugs
A
ondansetron (5-HT3 antagonist)
antihistamines
- hydroxyzine
- meclizine
promethazine (antipsychotic)
