AEDs

Question 1

older drugs

Answer 1

complex pharmacokinetics, high drug interaction risk, more adverse effects, greater experience

Question 2

what is pharmacokinetics

Answer 2

what your body does with the drug
1. absorption
2. distribution
3. metabolism
4. excretion

Question 3

carbamazepine

Answer 3

auto inducer, increases ability to break down other meds faster and does it to its self, able to cause M. acid, and Steven Johnsons

Question 4

valproic acid/divalproex

Answer 4

many different names but are not interchangeable, these drugs are better tolerable than other drugs, they are not an enzyme inducer and do not have any adverse effects

Question 5

main mechanism of working

Answer 5

slows brain activity

Question 6

CNS side effects

Answer 6

impaired cognition, dizziness, drowsiness, diplopia, ataxia, incoordination, weakness

Question 7

suicide risk

Answer 7

2x for the drugs topiramate and lamotrigine
unclear if the increase In risk is for these drugs or all of the AEDS

Question 8

pregnancy risk

Answer 8

older drugs have more risks than the newer drugs
newer drugs still have risks
it is dangerous to not be treated and pregnant
dangerous to mother and fetus if to have a seziure
FOLIC ACID to help offset the adverse effects
better to treat mother at the smallest dose of the safest drug

Question 9

newer drugs

Answer 9

straightforward pharmacokinetics
few interactions
fewer adverse effects

Question 10

linear pharmacokinetics

Answer 10

double the dose and double amount in blood

Question 11

if someone tests positive for HLA factor what drugs should they never take

Answer 11

carbamazepine
phenytoin
lamotrigine
oxcarbazepine

Question 12

lamotrigine

Answer 12

rash
Steven johnson
sucide

Question 13

gabapentin

Answer 13

nerve pain
drowsiness, nystagmus

Question 14

pregabalin

Answer 14

weight gain, angioedema
euphoria=CV

Question 15

topiramate

Answer 15

pain, migraines, weight loss
suicide
M. acid

Question 16

levetiracetam

Answer 16

IV
CNS effects
increase blood pressure

Question 17

oxcarbazepine

Answer 17

CNS effects
Steven johnson

Question 18

status epilepticus

Answer 18

ongoing seizure that lasts longer than normal

Question 19

what to treat status epileptics

Answer 19

benzos
- enhance GABA
and are avaiabible in other fast acting routes

Question 20

therapeutic drug monitoring

Answer 20

use blood levels which guide dosing

Question 21

stopping therapy

Answer 21

avoid abrupt withdrawal because seizures can reoccur and even worse because the neural pathways in brain are more sensitized

Question 22

ease of use

Answer 22

newer ones are easier to use because go the linear pharmacokinetics

Question 23

enzyme inducers and their impact on other medications

Answer 23

speeds up the metabolism of other durgs
- may need larger dose to combat this

Question 24

testing requirements

Answer 24

HLA: Steven johnson

Question 25

older drugs

Answer 25

carbamazepine
valproic acid