Acid Suppressants Flashcards
H2RA mechanism
blocks the histamine receptor which is one of three ways to activate the parietal cell
PPI mechanism
absorbed into the blood and into the parietal cell where it becomes active and blood the proton pump which blocks H+ from going into stomach
antacid mechanism
neutralized the secreted acid
sucralfate
works with aluminum to make a paste that is consolable and will cover a ulcer by acting with the positive charged amino acids
what drugs last the longest
PPIs last the longest and antacids last the shortest
since antacids last the shortest what does that mean for drugs that need an acidic stomach to become activated
you need to use these for those drugs and have them spaced out by 2 hours
importance of NOT crushing the PPI
if crushed the drug will be activated in the stomach and will not work because it won’t be absorbed into blood and will not become activated in parietal cell
long term risks of PPI
increase risk of bone fractures, vitamin mineral malabsorption
short term risks of PPi
headache, N, diarreah, abdominal pain
what do Al, Mg, and Ca cause
Al: neurotoxicity, constipation
Mg: diarrhea
Ca: constipation
what severe side effect is common for all acid reducers
chelation: drug absorbs a metal in stomach and cannot go into blood to work
how can chelation be minimized
take the drugs at separate times
specific risks of antacids
constipation= AL and Ca
diarrhea= MG
neurotoxicity = AL
decrease phostphate
chelation
risks of sucralfate
bezoar: formation of insoluble mass
constipation
decrease phosphate
chelation
H2RA drugs
ranitidine
famotidine
