Statins Flashcards
general mechanism of action
block the enzyme needed by the liver to produce its own cholesterol to produce bile acids
this causes the liver to increase its LDL receptors and only use exclusively free floating LDL to make bile acids
impact on TC, LDL, HDL, and TG
TD: decrease
LDL: decrease
HDL: neutral/increase
TG: slight decrease
impact on clinical outcomes
decrease MI risk, CAD, stroke
increase survival
lipids vs lipoproteins
lipids are fatty acids and insoluble in water
lipoproteins carry cholesterol and triglycerides and have proteins on the surface which allow tissues to up take the cholesterol and triglycerides
surrogate vs clinical outcomes
surrogate is the value affected
clinical outcomes is how it affects the patient
EX: surgery and statins both lower LDL (surrogate) bur statins dercrease CAD risk (clinical outcome)
dose response relationship
flat
dosing
start high
time of day
evening because most cholesterol is made then
risk factors: severe
myalgias: aches pains
myopathies: ache/pain with break down
rabdo: breakdown so severe the proteins damage other organs
risk factors: mild
heart burn
head ache
taste disturbances
diabetes
statins drugs
statins
- lovastatin
- pravastatin
- simvastatin
- atorvastatin
- rosuvastatin
the more lipid in a lipoprotein the
lower the density
this is the ____ standard for lowering LDL
gold
