Antidepressants Flashcards
TCA drugs
amitriptyline
nortriptyline
SSRIs
fluoxetine
paroxetine
sertraline
citalopram
escitalopram
SNRIs
venlafaxine
desvenlaflaxine
duloxetine
others
bupropion
mirtazapine
trazadone
general mechanism of action
all antidepressants work by increasing neurotransmitters
monoamine deficiency hypothesis
major depression is caused by a relative lack of neurotransmitters
why does it take a long time for full effects to be seen
this is because antidepressants resensitize the pathways of neurotransmitters and this takes time
what do all antidepressants cause
weight gain
sucicide risk (increase in younger)
sexual dysfunction
TCAs adverse effects
orthostatic hypotension, sedation, anti SLUD, sweating, cardiotoxcity, seizures, suicide risk
most effects are due to blocking other receptors
SSRI adverse effects
serotonin syndrome, withdrawal anti platelet, osteoporosis
SNRI adverse effects
serotonin syndrome, withdrawal anti platelet, osteoporosis
and hypertension
what is serotonin syndrome
what are risk factors
too much serotonin stimulation
altered mental status, incoordination, myoclonus, hyperreflexia, excessive sweating, tremor, fever
big doses or taking more than one drug that stimulates serotonin
big concern with TCAs that caused new development of drugs
suicide risk
over doses are fatal
advantages of bupropion
lowest risk of impotence and weight gain
TCAs drugs
amitriptyline
nortriptyline
