Antiarrhythmics Flashcards
classes
class 1: sodium channel blockers
class 2: beta blockers
class 3: prolonged repolarization
class 4: calcium blockers
what classes affect rate
class 2, class 4
what classes affect the rhythm
class 1, class 3
what class is amiodrone
class 3 but has properties from all classes
what class is flecanide
class 1
what is the biggest risk to developing a new arrhythmia
structural damage
rule of 5
to find out how long the drug will be in your system multiply the half life by 5
loading doses
for longer half life drugs we will give a loading dose which is a extremely large dose for the first few weeks to build up the drug in the body so we can get a reaction sooner
amiodrone effects
hyper/hypo thyroid, pulmonary fibrosis, liver toxicity, dermatologic toxcicites, opthalmogic toxicities, Bradycardia and hypotension
why does amidorone cause thyroid issues
this is because the iodine in the drug will trick the body into thinking you have enough thyroid hormone or using it to make more
what is the dermatologic issue with amidodrone
blue/gray skin
why does amiodrone cause bradycardia and hypotension
this is more common via the IV route and this is due to beta blocking properties
what is one value you need to monitor for amiodrone
TSH
- if TSH is high then you have hypothyroidism
- if TSH is low then you have hyperthyroidism
flecanide risks
dizziness, visual disturbances, dyspnea, TdP
who are more at risk for TdP
structural damage to the heart
- ischemia, hypertrophy, myopathy, Hf
