Diuretics

Question 1

general mechanism of action

Answer 1

works in the kidney to prevent sodium reabsorption

Question 2

when would you use thiazide vs loop

Answer 2

thiazide for hypertension and loops for edema/fluid retention

Question 3

loops

Answer 3

work in the loop of henle and are the strongest, linear response curve, can handle larger doses, used for fluid retention

Question 4

thiazide

Answer 4

flat response curve, small dosing, hypertension, second strongest, works in the distal tubule

Question 5

potassium sparing

Answer 5

weakest, works in distal tubule and to the collecting duct, normally used in combo to help eliminate side effects

Question 6

loops electrolyte side effects

Answer 6

decrease ca, k, mg

Question 7

loops sensitivity to renal function

Answer 7

work dispute the renal function because these work in the blood

Question 8

thiazide electrolyte side effects

Answer 8

increase ca, decrease k and mg

Question 9

thiazide to renal funciton

Answer 9

doesn’t work if renal function is low because not enough drug is filtered to work

Question 10

k sparing electrolte effects

Answer 10

increase K, decrease mg

Question 11

main side effects

Answer 11

hypovolemia, hypotension, dizziness, hyperglycemia, increase choltererol and tris, hyperuricemia, impotence

Question 12

spironolactone uses, mechanisms, side effects

Answer 12

heart failure
aldosterone and tesoterone blocker
gynecomastia

Question 13

loop drugs

Answer 13

furosemide
torsemide

Question 14

thiazide

Answer 14

hydrochlorothiazide
chlorothalodone

Question 15

K sparing

Answer 15

spironolactone, triamterene

Question 16

interactions

Answer 16

lithium: when on Li kidney cells will reabsorb Li over sodium so this can lead to Li toxicity
when taking any other antihypertensive and paired with a diuretic this will work better because the body notices and compensates via the kidney