NSAIDS & Acetaminophen Flashcards
nonselective vs cox2 selective
nonselective: blocks both cox1 and cox2, increase risk of GI related issues but decrease risk of cardio toxicity
cox2 selective: only blocks cox2 which is released by damaged cells, decrease risk of GI related issues but increase risk of cardiotoxicty
cox1 vs cox2
cox1: released all of the time, normal prostaglandins
cox2: only released by damaged tissue
NSAIDS vs acetaminophen in method of action
NSAIDS works in CNS and PNS so there is some aids in swelling
acetaminophen only works in CNS
NSAID and acetaminophen in pain relief and fever
works very similar
how do NSAIDs cause GI ulcers and bleeding
decrease the prostaglandins which are important in the stomach to maintain the stomach lining
risk factors of NSAID bleeding
steroids, aspirin, warfarin
history of ulcer and bleeding
>65 yrs
how to minimize risk of GI ulcer and bleeding
PPI
switch to COX2 selective NSAID
why not to use NSAID with ACEI or ARBs
NSAIDS constricts afferent arteriol= decrease pressure
ACEI/ARBS dilates the efferent which decrease pressure
when taking both this can lead to kidney failure
cardiac risks of NSAIDS
COX2 selective have increased risk of cardio toxicity but less risk of GI issues
ketorolac
do not take longer than 5 days
change dose if over 65 yrs old and under 50 kg
cannot take if: prior or active ulcer, renal disease or risk, increase bleeding, taking ASA, NSAID or probenecid
nonselective NSAIDS
ibprophen
meloxicam
naproxen
diclofenac
ketorolac
selective cox2 NSAID
celecoxib
how to acetaminophen and NSAID decrease pain
decrease prostaglandin in the brain which sense pain
will enteric coated NSAID help with ulcers
NO, this is because it is not the pill it self that causes ulcers, it is the action of decreasing the prostaglandin
other side effects of NSAIDS
decrease renal function, decrease platelet function, kidney toxicity, hypertension
