SYSTEMIC LUPUS ERYTHEMATOSUS

Question 1

In SLE, the immunoregulatory disturbance is thought to be brought about by some combination of four distinct factors

Answer 1

*genetic
*immunologic
*hormonal
*environmental

Question 2

antibody that develops against DNA that is highly specific to SLE

Answer 2

Anti-DNA

Question 3

antibody against DNA that is highly specific to SLE, which helps differentiate it from drug-induced lupus

Answer 3

Anti-ds DNA

Question 4

Antibody against Sm, which is a specific protein found in the nucleus.

Answer 4

Anti-Sm

Question 5

The mainstay of SLE treatment is based on

Answer 5

pain management and nonspecific immunosuppression.

Question 6

is a monoclonal antibody that specifically recognizes and binds to BLyS. It prevents it from binding to B-cell surfaces and stimulating B-cell activity.

Answer 6

Belimumab

Question 7

acts to stimulate B-cells to produce antibodies against the body’s own nuclei.

Answer 7

BLyS

Question 8

An antimalarial medication effective for managing cutaneous, musculoskeletal, and mild systemic features of SLE.

Answer 8

Hydroxychloroquine

Question 9

What are the immunosuppressive agents reserved for patient who have serious forms of SLE that have not responded to conservative therapies?

Answer 9

*cyclophosphamide
*mycophenolic acid
*methotrexate
*azathioprine

Question 10

One of the most important risk factors associated with the use of corticosteroids in SLE is

Answer 10

Osteoporosis and fractures