PARKINSON'S DISEASE Flashcards
is a slow progressing neurologic movement disorder that eventually leads to disability.
Parkinson’s Disease
Parkinson’s Disease is associated with decreased levels of
Dopamine
What neurotransmitters are imbalanced in Parkinson’s Disease?
Acetylcholine and Dopamine Neurotransmitters
Cardinal signs of Parkinson’s Disease
*Tremor
*Rigidity
*Bradykinesia/Akinesia
*Postural Instability
Two major subtypes of Parkinson’s Disease:
*Tremor Dominant
*Non-tremor Dominant
Resistance to passive limb movement characterizes
muscle rigidity
Passive movement of an extremity may cause the limb to move in jerky increments, referred to as
lead-pipe or cog-wheel movement
A common feature of Parkinson’s Disease
Bradykinesia
refers to the overall slowing of active movement.
Bradykinesia
Diagnosis of Parkinson’s Disease is often confirmed by
a positive response to a Levodopa trial.
is a helpful assessment tool as it measures the disease progression including motor and nonmotor symptoms.
Revised Movement Disorder Society Unified Parkinson Disease Rating Scale (MDS-UPDRS)
is the most effective agent and the mainstay of treatment.
Levodopa
Levodopa is converted into _____ in the basal ganglia, producing symptom relief.
Dopamine
are ablative procedures that were formerly used to relieve symptoms of Parkinson’s Disease such as tremors.
Thalamotomy and Pallidotomy
has largely replaced ablative procedures in the surgical treatment of Parkinson’s Disease
Deep Brain Stimulation (DBS)
