STDs Flashcards
Immunodeficiency disorders in which human immunodeficiency virus uses T4 (CD4) cells as a receptor and reservoir for HIV
Acquired Immune Deficiency Syndrome (AIDS)
Epidemiology: HIV
1. Modes of transmission similar to those of hepatitis B but
specifically: Blood, semen, vaginal secretions, and
breast milk
2. Risk of infection via needle stick is approximately _____
1:350
Signs/Symptoms: HIV
- _____ ____ symptoms: Think seroconversion (a process of converting from HIV negative to HIV positive; the process takes approximately ___ weeks to 6 months)
- Early s/s include: _____, night sweats, and weight loss
- Flu-like
3 weeks - Fever
- It is more a constellation of signs/symptoms than any single one that is suspicious for AIDS AIDS = CD4 < ____ cells/uL and/or the presence of an opportunistic infection
200
Laboratory/ Diagnostics: HIV
1. _____ for initial screening; sensitivity > 99.9%
2. Western Blot test is confirmatory
3. Latest recommended HIV tests:
a. HIV-1/2 antigen/antibody combination immunoassay;
if positive, proceed to:
b. HIV-1/2 antibody differentiation immunoassay
4. Absolute CD4 lymphocyte count: Normal > ____
cells/uL
5. CD4 lymphocyte percentage
a. Risk of progression to AIDS high when < 20%
6. Viral load
a. ____: Based quantitative copies of HIV-branched
DNA or RNA
b. Results correlate closely with the progression of HIV
c. Ideally should be “zero” or “detectable”
- ELISA
- 800
- a. PCR
Management: HIV
1. Therapy for Opportunistic Infections
a. Treat infection as it occurs
b. Bactrim for ___ _____ pneumonia
prophylaxis
2. Antiretroviral Treatment
a. Combination therapy is standard [____ ____ ____
(__)]
b. When to start AART remains somewhat
controversial.
CDC and UDDHS recommend starting medications
at
the time of HIV+ diagnosis
3. Monitor for the danger of drug resistance: Must be
taken exactly as prescribed!
- b. Pneumocystis jirovecii
2. a. Active Antiretroviral Therapy (AART)
Cause: Haemophilus ducreyi, a gram-negative bacillus
Chancroid
Prevalence: Chancroid
- Endemic in many areas of the United States; must be a part of the differential diagnosis for genital ulcers
- Well established as a co-factor for H1V transmission (high rate of HIV identified among individuals presenting with chancroid)
- Estimated up to ___% of patients are also infected with syphilis and HSV
- 10%
Signs/Symptoms: __________
I. Women: Usually asymptomatic
2. Men: Single (or multiple) superficials, painful ulcer,
surrounded by an erythematous halo
3. Ulcers may be necrotic or seVerely erosive
Chancroid
Diagnosis: Chancroid
- A probable diagnosis is usually a matter of exclusion
- Involves genitalia and unilateral bubo (or both)
- Painful genital ulcers in absence of ___ ____ and HSV (by inspection or culture) with coexisting tender inguinal lymphadenopathy is suggestive of chancroid
- The definitive diagnosis of chancroid is made morphologically (sensitivity no > 80%)
- T pallidum
a. _______: The degree to which those Who have a
disease screen/ test positive
Sensitivity
b. ______: The degree to which those who do not
have a disease screen/test negative
Specificity
Treatment: Chancroid
- ______ (Zithromax) t gram by mouth x 1 dose or
- Ceftriaxone (Rocephin) 250 mg IM x i dose or
- Ciprofloxacin (Cipro) 500 mg by mouth twice a day × 3 days
- Azithromycin
A parasitic STD caused by Chlamydia trachomatis that produces serious reproductive tract complications in either sex
Chlamydia
Signs/Symptoms of Chlamydia: Females: Often asymptomatic 1. Dysuria 2. Intramenstrual spotting 3. Postcoital bleeding 4. Dyspareunia: \_\_\_\_\_ intercourse 5. Vaginal discharge
- Painful
Males: Often asymptomatic Chlamydia:
- ______
- Thick, cloudy penile discharge
- Testicular pain
- Dysuria
Laboratory/Diagnostics: Chlamydia
1. Chlamydia culture is the most definitive test (3 to 9 days
for results)
2. ____ _____ (__) methods preferred (low
cost; 30 to 120 min for results)
- Enzyme immunoassay (EIA)
Treatment: Chlamydia
1. ______ (Zithromax) 1 gram by mouth x 1 dose OR
2. Doxycycline (Vibramycin) 100 mg by mouth twice a day
x 7 days
3. Alternatives: Erythromycin, Ofloxacin, Levofloxacin
4. Report to the ______ department
- Azithromycin
4. health
Cause: Human papillomavirus (HPV)
Genital Warts (Condyloma acuminata)
Prevalence
- The most common viral STD in the United States
- An estimated 3 million cases of HPV (including cervical HPV) are reported annually
Genital Warts (Condyloma acuminata)
Symptoms: Genital Warts (Condyloma acuminata)
Single (or multiple) soft, fleshy, papillary, or sessile, painless _____ growth around the anus, vulvovaginal area, penis, urethra, or perineum
keratinized
Diagnosis: Genital Warts (Condyloma acuminata)
- Clinical presentation; perhaps atypical ___ _____ of undetermined significance (ASCUS) or squamous intraepithelial lesion (SIL) on PAP smear
- Colposcopy useful in diagnosing fiat lesions
- May need to biopsy if at risk for cervical intraepithelial neoplasia (CIN)
- squamous cell
Treatment: Genital Warts (Condyloma acuminata)
- Keratolytic agents: Podophyllin (Pododema), trichloroacetic acid (TCA), or trichloroacetic acid (BCA)
- Referral for cryotherapy, ____ therapy, electrocautery, or excision
- laser
Prevention
- Gardasil [Human Papillomavirus Quadrivalent (Types __, __, __, and ___) Vaccination]
a. Indicated for females and males ages 9 to 26 years
b. Given in 3 injections - Cervarix [Human Papillomavirus Bivalent (Types 16 and 18) Vaccination]
a. Indicated for females ages 10 to 25 years
b. Same as above
6, 11, 16, and 18
________
A bacterial STD caused by Neisseria gonorrhoeae (gram-negative diplococci); causative organism may be cultured from the genitourinary tract, oropharynx, and/or anorectal
Gonorrhea
Incidence/General Concepts: Gonorrhea
- Produces _____ in men and cervicitis in women
- A leading cause of infertility among females in the United States
- Affects 1 to 2% of the general population
- Male to female transmission is 80 to 90% after exposure
- urethritis
Incidence/General Concepts: Gonorrhea
- Produces _____ in men and cervicitis in women
- A leading cause of infertility among females in the United States
- Affects 1 to 2% of the general population
- Male to female transmission is 80 to 90% after exposure
- urethritis
Signs/Symptoms: Gonorrhea Females: Often asymptomatic (80%) 1. Dysuria 2. \_\_\_\_\_ \_\_\_\_\_ 3. Mucopurulent vaginal discharge (green) 4. Labial pain and swelling 5. Lower abdominal pain 6. \_\_\_\_ 7. Abnormal menstrual periods 8. Dysmenorrhea
Males: Often asymptomatic
- Dysuria
- Frequency
- White/yellow-green penile discharge
- _____ ____
- N and V
Female:
- Urinary frequency
- Fever
Male:
4. Testicular pain
Treatment: Gonorrhea
1. ______ (Rocephin) 250 mg IM × 1 dose to treat
gonorrhea plus
2. Azithromycin (Zithromax) 1 gram orally × 1 dose to cover chlamydia
3. Report to the health department
- Ceftriaxone
Laboratory/Diagnostics: Gonorrhea
- Gram stain of discharge smear shows gram-negative diplococci and WBC
- Cervical culture for ___ ______ using modified Thayer-Martin media
- N. gononhoeae
_______ ___
Cause: Hepatitis B virus (HBV)
Hepatitis B
Prevention: Hepatitis B
1. Two commercially available hepatitis B preventive vaccines administered at ___, ____, _____ months: Recombivax HB and Engerix-B
0, 1, and 6
Treatment: Hepatitis B
- Supportive and symptomatic care
- _____ ___ immune globulin (HBIG) 0.06 ml/kg IM in a single dose within 14 days of exposure (earlier administration may be more effective)
- Hepatitis B
A recurrent viral STD with no cure, associated with painful genital lesions
Herpes
Herpes:
_______: Direct contact with active lesions or vires-containing fluid (saliva or cervical secretions)
Transmission
Herpes Simplex Virus ___ ___: Associated with infection of lips, face, and mucosa
Type 1
Signs/Symptoms:
- Initial: Fever, malaise, dysuria, painful/pruritic ulcers for usually ___ days
- Recurrent: Less painful/pruritic ulcers for usually 5 days
- Herpetic whitlow: HSV-I=60%, HSV-2=40%
- 12
Herpes Simplex Virus ____ ___: Associated with the genitalia
Type 2
Management Herpes:
No treatment for curing the disease
Symptomatic treatment with drying and antipruritic agents
_______ (Zovirax) recommended for topical, oral, and IV use FamcMovir
Valacyclovir: Especially useful for asymptomatic viral shedding of HSV2
Acyclovir
Laboratory/Diagnostics: Herpes
- ______ or Tzanck stain
- The most definitive test is viral culture
- Papanicolaou
Cause:
Immunotypes L1, L2, or L3 of Chlamydia trachomatis
Lymphogranuloma Venereum (LGV)
Signs/Symptoms: Lymphogranuloma Venereum (LGV)
1. ____mm painless vesicle, bubo, or non-indurated ulcer
2. Regional adenopathy follows in approximately one month and is the most common finding
3. Stiffness and aching in groin followed by unilateral
swelling of inguinal region
- 2 to 3 mm
Diagnosis: Lymphogranuloma Venereum (LGV)
1. May be confused with chancroid
2. Definitive diagnosis requires isolating C. _____
from an appropriate specimen
- trachomatis
Treatment: Lymphogranuloma Venereum (LGV)
- _______ (Vibramycin) 100 mg orally twice a day x 21 days
- Aspirate buboes to prevent ulcerations
- Doxycycline
Cause: Molluscum contagiosum virus
Molluscum Contagiosum
Prevalence: Molluscum Contagiosum
1. Occurs infrequently, about 1 for every ____ cases of GC
100
Signs/Symptoms: Molluscum Contagiosum
- Lesions are ______mm, smooth, rounded, firm, shiny flesh-colored to pearly-white papules
- Commonly seen on the trunk and anogenital region
1 to 5 mm
Diagnosis: Molluscum Contagiosum
1. Inspection and _____ exam
microscopic
Treatment: Molluscum Contagiosum
1. ______ with liquid nitrogen: Most popular method; may resolve without scarfing
Cryoanesthesia
STD involving multiple organ systems
Syphilis
Cause: Syphilis
Treponema pallidum, a _____ with 6 to 14 regular spirals
spirochete
Incidence/General Concepts
- The third most commonly reported infectious disease in the United States
- Approximately _____ new cases reported annually
- 200,000
Four Clinical Stages & Syphilis:
_________
Seropositive, but asymptomatic
Latent
Four Clinical Stages & Syphilis: \_\_\_\_\_\_\_\_\_\_\_ a. A chancre is painless b. Indurated ulcer c. Located at the site of exposure
Primary
Four Clinical Stages & Syphilis: \_\_\_\_\_\_\_\_\_ a. Flu-like symptoms b. Highly variable skin rash on palmar and plantar surfaces; mucous patches c. Lymphadenopathy d. Malaise e. Anorexia f. Alopecia g. Arthralgias
Secondary
Four Clinical Stages & Syphilis: \_\_\_\_\_\_ a. Leukoplakia b. Cardiac insufficiency c. Aortic aneurysm d. Meningitis e. Hemiparesis f. Hemiplegia
Tertiary
Serologic Tests: Syphilis
1. Nontreponemal: VDRL/RPR
2. Treponemal:
a. _________ treponemal antibody absorption (FTA-
ABS): Confirms positive in 85 to 95% of primary
cases and 100% of secondary cases
Microhemaggluthaation assay for antibody to T.
pallidum (MHA-TP)
- a. Fluorescent
Treatment
- Primary, secondary, or early syphilis of less than 1-year duration
a. _____ _____ G 2.4 million traits IM
- a. Benzathine penicillin
Treatment
2. Late, latent, and indeterminate length; tertiary stage
a. Benzathine penicillin G 2.4 million traits IM weekly x 3
weeks
3. Penicillin allergic
a. _______ 100 mg orally twice a day, or
b. Erythromycin 500 mg orally four times a day
4. Report to the health department
- a. Doxycycline
Tanner staging for girls: breast development
a. ________ breast
b. Breast buds with areolar enlargement
c. Breast enlargement without separate nipple contour
d. _____ and nipple project as a secondary mound
e. Adult breast: Areola recedes, nipples retracts
a. Preadolescent
d. Areola
The absence of menstrual flow
Amenorrhea
Absence of menarche by age 16
Primary Amenorrhea
Cessation of menstrual flow after the establishment of normal menstrual cycling
Secondary Amenorrhea