Oral Contraceptives Flashcards
Tablets are taken daily which contain estrogen and/ or progestin whose purpose is to interfere with fertilization or implantation or both to prevent pregnancy and/ or control the menstrual cycle
Oral contraceptives
______ pills alter the dosage of estrogen and progestin throughout the cycle and
Combined
Ethinylestradiol + norgestimate examples are?
Ortho- Cyclen, Ortho Tri-Cyclen, Ortho Tri-Cyclen Lo
Ethinyl estradiol or mestranol, synthetic _____
estrogen
Norethindrone, norethindrone acetate, ethanediol diacetate, norethynodrel, norgestrel, Levonorgestrel, desogestrel, gestodene, norgestimate, all ________
progestins
\_\_\_\_ \_\_\_\_\_ (mini-pills) are not as effective as combination pills a) Mechanism of action affects the cervical mucus and the endometrium, most likely changes tubal transport of oocyte and sperm
Progestin-only
Typical first-year failure of birth control is?
3%
Typical first-year failure rate (age < 22 years):
______?
4.7%
Mechanism of action:
_______ effects
a) Ovulation inhibited by suppression of FSH/ LH
b) Implantation inhibited by alteration of the endometrium
c) Ovum transport is accelerated
d) Luteorlysis may occur as estrogen causes progesterone level to fall
Estrogenic
Mechanism of action:
_____ effects
a) Thick cervical mucus interferes with sperm transport
b) Capacitation may be inhibited
c) Ovum transport may be slowed
d) Implatiaotn is hampered by suppression of the endometrium
e) Ovulation inhibited by hypothalamic-pituitary-ovarian disturbances
Progestational effects
Advantage contraceptive:
Excellent ______ against unwanted pregnancy; may lead to fuller sexual satisfaction due to a reduction in fear of pregnancy
protection
The advantage of contraceptives is ____ for most females?
safe
The advantage of contraceptive is less _____ blood flow (non-contraaceptive benefit)
Menstrual
The advantage of contraceptive is an improvement in facial ___ (non- contraceptive benefits)
acne
The advantage of contraceptive is woman controls own _____
fertility
The advantage of contraceptive is excellent _______ and easy to use
reversibility
An advantage of contraceptive is well _______
researched
An advantage may provide protection against ovarian and endometrial cancer, ectopic pregnancy, ____ _____ ____ (____) , functional ovarian cyst, endometriosis, uterine fibroids, among others
pelvic inflammatory disease (PID)
A disadvantage of contraception is:
a) May lead to _____ changes
mood
A disadvantage of contraception is:
b) No protection against _____
b) HIV
A disadvantage of contraception is:
c) ______ for some women
Expensive
A disadvantage of contraception is:
d) Rare circulatory _______ which may be dangerous
d) complications
A disadvantage of contraception is:
e) Increased risk of rare liver _____
e) tumors
A disadvantage of contraception is:
f) Pills must be taken _____ ____
f) every day
A disadvantage of contraception is:
g) Possible side effects such as ______, headaches, breakthrough bleeding
g) nausea
Undesirable Hormonal effects: 1) Excessive estrogenic effects a) \_\_\_\_\_\_\_\_ b) nausea c) chloasma d) Cerebrovascular accidents (CVA) e) Deep venous thrombosis (DVT) f) Thromboembolic disease g) \_\_\_\_\_\_ emboli h) Telangiectasias i) Hepatic adenoma/ adenocarcinoma j) Cervical changes k) \_\_\_\_\_\_ tenderness (secondary to increased size)
a) dysmenorrhea
g) Pulmonary
k) Breast
Deficiency in estrogen:
a) No withdrawal bleeding
b) Decreased duration in menstrual bleeding
c) Continuous spotting/ bleeding
d) breakthrough _______ on Day of cycle (DOC) 1 to 9
e) Atrophic vaginitis
d) bleeding
Excessive progestational effects
a) breast tenderness
b) transient hypertension
c) _______
d) fatigue
e) decreased libido
f) decreased duration in menstrual bleeding
g) increased ______
c) depression
g) appetite
Decreased Progestone effects
a) breakthrough _____ DOC 10 to 21
b) delayed menses
a) bleeding
Excessive androgenic effects
a) Hirsutism
b) Acne
c) Oily skin
d) ______
e) Increased Libido
d) Edema
Excessive estrogen/ deficient progesterone combination
a) __________
b) Menorrhagia
c) Nausea
d) _______
e) Headache
f) Irritability
g) bloating/ edema
h) _____
a) Dysmenorrhea
d) vomiting
h) syncope
Absolute contraindications for contraceptive
1) History of thromboembolic disorders
2) CVA (history of)
3) Coronary artery disease (CAD)
4) Known or suspected breast ________
5) Known or suspected estrogen-dependent neoplasia
6) Pregnancy
7) Benign or malignant liver tumor; impaired liver function
8) Previous cholelithiasis during pregnancy
9) Undiagnosed, abnormal uterine bleeding
4) carcinoma
Management/ Prescriptive Guidelines: 1. General considerations a) Begin with low-dose combined or multiphasic pill ( \_\_\_ mcg or less) b) \_\_\_\_\_-only pills may be used in women with a history of migraines headaches, who are breastfeeding or who have some contraindications to the combination pills
1) a) 35 mcg
b) Progestin
Patient education with contraception:
a) Instructions for use/ how the ___ works
b) “Missed” pills and backup contraception
a) pill
Adverse effects of contraception:
a) Abnormal menstrual bleeding: ____ ____ and spotting may be common; may need a higher dose
breakthrough bleeding
Adverse effects of contraception:
b) Amenorrhea or ______: Often caused by a low amount of progestin; may need dose increased
b) hypermenorrhea
Adverse effects of contraception:
c) Birth defects: Estrogen = pregnancy category ___, immediately discontinue oral contraceptives (OCs) if pregnant
c) X
Adverse effects of contraception:
d) ___: Estrogens promote certain types of breast CA family history should not take OCs
d) Cancer
Adverse effects of contraception:
e) ____: Risk is increased with age, dose, and length of therapy
e) Hypertension
Adverse effects of contraception:
f) Weight gain, increased _____, fatigue, depression, acne, and hirsutism: often caused by high amounts of progestin; may need a lower dose
appetite
Adverse effects of contraception:
g. Nausea, ______, and breast tenderness: Caused by high amounts of estrogen; may need a lower dose
g. edema
Adverse effects of contraception:
h. _______ disorders: Increased risk in some patients; OCs contraindicated inpatient with a history of thromboembolic disorders. CVA, CAD, or heavy smokers
h. Thromboembolic
Adverse effects of contraception:
i. Durg-drug interactions: Certain antibiotics and anticonvulsant decrease the effectiveness of OCs; OCs decrease the effectiveness of ____, _____ and certain oral hypoglycemic
i. warfarin, insulin
A flexible, prescriptive contraceptive ring, approximately 2 inches in diameter, for the purpose of preventing pregnancy
NuvaRing
Effectiveness:
NuvaRing typical failure rate: < ___ to __%
< 1 to 2%
Effectiveness of NuvaRing:
Reported manufacturer effectiveness: ___ to ___%
92 to 99.7 %
Mechanism of Action with NuvaRing:
1. Releases synthetic ______ (etonogestrel), Providing pregnancy protection for 1 month
estrogen and progestin
Mechanism of Action with NuvaRing:
2. Release of hormones is activated by _____ contact
vaginal
Mechanism of Action with NuvaRing:
3. Prevents _____; thickens the vertical mucus, inhibiting sperm penetration
ovulation
Mechanism of Action with NuvaRing:
4. May alter the _______ to affect implantation
endometrium
Advantages of NuvaRing:
- Convenient
- Once per ___ insertion
- month
Advantages of NuvaRing:
3. Easily
- reversible
Advantages of NuvaRing:
4. ____ ___require partner participation, thus sexual is not interrupted
- Does not
Advantages of NuvaRing:
5. Fewer ____ swings reported than with oral contraceptives
- mood
Advantages of NuvaRing:
6. Discreet: Usually, ____ be felt by the patient or partner
- cannot
Advantages of NuvaRing:
7. May lead to shorter, _____, and more regular menstrual periods.
- lighter
Advantages of NuvaRing:
8. Assume to offer additional similar non-contraceptive benefits of oral contraceptives ( e.g., decreased menstrual ____, improvement of facial acne, depression, etc.)
- cramps
The disadvantage of NuvaRing:
1. Similar to OCs ( e.g. ____ tenderness, headaches, weight gain, nausea, mood change, breakthrough bleeding, yet a lower incidence compared to oral contraceptives
breast
The disadvantage of NuvaRing:
2. Increased ____ discharge, irritation, or infection
vaginal
The disadvantage of NuvaRing:
3. Diaphragms, vertical caps, or shields ____be used as a back-up method of contraception while using the ring
cannot
The disadvantage of NuvaRing:
4. May ____depression in the patient previously diagnosed
worsen