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Micro Term 4 > Skin VI > Flashcards

Skin VI Flashcards

1
Q

describe the genetic composition of poxviruses

A

enveloped dsDNA

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2
Q

poxviruses multiply in ___ (unique among DNA viruses)

A

poxviruses multiply in the cytoplasm in factory areas (unique among DNA viruses)

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3
Q

list the sequence in clinical presentation of smallpox

A
  1. flu-like symptoms for 2-4 days
  2. simultaneous eruptive skin pustules (synchronous): start on mouth and spread everywhere in <24 hours
  3. vomiting, diarrhea, bleeding
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4
Q

the eruptive skin pustules seen in smallpox are described as being ____

A

the eruptive skin pustules seen in smallpox are described as being synchronous

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5
Q

exposure to smallpox is through ____

A

exposure to smallpox is through inhalation, contact or fomites

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6
Q

describe variola major vs. variola minor

A
  • variola major: highly virulent, caused toxemia, shock and intravascular coagulation
  • variola minor: less virulent
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7
Q

smallpox multiplies in the ____ before traveling to the lymphatics where it becomes disseminated

A

smallpox multiplies in the URT before traveling to the lymphatics where it becomes disseminated

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8
Q

chickenpox and shingles are part of the ___ family of viruses

A

chickenpox and shingles are part of the Herpesvirus family of viruses

enveloped linear dsDNA

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9
Q

describe the genetic composition of chickenpox

A

enveloped, linear dsDNA

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10
Q

the cytopathic effect of chickenpox and shingles is forming ___

A

the cytopathic effect of chickenpox and shingles is forming syncytia (enveloped viruses tend to form syncytia)

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11
Q

the species of chickenpox and shingles is HHV-___

A

the species of chickenpox and shingles is HHV-3

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12
Q

the target of chickenpox and shingles is…. (4 things)

A

the target of chickenpox and shingles is:

epithelial cells

fibroblasts

T cells

neurons

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13
Q

the skin lesions seen in chickenpox is described as ____ (when compared to smallpox)

A

the skin lesions seen in chickenpox is described as asynchronous (when compared to smallpox, which is synchronous)

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14
Q

chickenpox has a tropism for ____ and then enters ____ and remains latent

A

chickenpox has a tropism for T-cells (skin-homing markers) and then enters neurons and remains latent

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15
Q

the spread of the rash seen in chickenpox is described as (centripetal or centrifugal?)

A

the spread of the rash seen in chickenpox is described as centrifugal

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16
Q

describe what asynchronous presentation in chickenpox means

A
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17
Q

after resolution of shingles, many individuals continue to experience pain in the distribution of the rash, which is called ____

A

after resolution of shingles, many individuals continue to experience pain in the distribution of the rash, which is called postherpetic neuralgia

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18
Q

list factors that predispose shingles

A

stress, x-ray treatments, drug therapy, developing malignancy

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19
Q

describe the clinical presentation of congenital varicella

20
Q

there is decreasing incidence of chickenpox in the US due to ____

A

there is decreasing incidence of chickenpox in the US due to effective childhood vaccine

21
Q

the prevention of chickenpox/shingles is via ____

A

the prevention of chickenpox/shingles is via live attenuated vaccine

22
Q

describe HSV-1; it usually occurs in ___ (age)

A

usually lesions on the oropharynx, cold sores, fever, blisters

usually occurs in early childhood

23
Q

describe HSV-2; usually occurs in ____ (age)

A

lesions on the genitalia, possibly oral

occurs in ages 14-29

can be spread without visible lesions

24
Q

describe the clinical presentation of HSV-1

25
the most significant transmission of herpes simplex is caused by \_\_\_\_
the most significant transmission of herpes simplex is caused by **active lesions**
26
HSV multiples in ___ and moves to \_\_\_\_
HSV multiples in **sensory neurons** and moves to **ganglia** ## Footnote **trigeminal = HSV1** **sacral = HSV2**
27
herpes simplex is potentially fatal in \_\_\_\_
herpes simplex is potentially fatal in **the neonate and fetus**
28
scrapings from the base of herpes simplex lesions show \_\_\_\_
scrapings from the base of herpes simplex lesions show **giant cells**
29
coxsackievirus is part of the ___ family of viruses
coxsackievirus is part of the **picornavirus** family of viruses
30
describe the genetic composition of coxsackievirus
**small, nonenveloped, ssRNA**
31
hand foot and mouth disease is caused by \_\_\_\_
hand foot and mouth disease is caused by **coxsackievirus A16**
32
describe the clinical presentation of HFMD
* at first: tired, sore throat, fever * in 1 day or 2: painful sores or blisters may appear in or on the mouth and on the hands, feet
33
HFMD commonly occurs in \_\_\_\_
HFMD commonly occurs in **children \< 5 years old**
34
herpangina is characterized by fever and a painful \_\_\_\_
herpangina is characterized by fever and a painful **papulo-vesiculo-ulcerative oral enanthem**
35
herpangina is most commonly caused by ____ serotypes
herpangina is most commonly caused by **coxsackievirus A** serotypes
36
herpangina is usually spread via the ___ or ___ route
herpangina is usually spread via the **fecal-oral** or **respiratory** route
37
after clinical symptoms of herpangina have resolved, asymptomatic enteroviral infection may persist in the \_\_\_\_
after clinical symptoms of herpangina have resolved, asymptomatic enteroviral infection may persist in the **GI tract**
38
molluscum contagiosum is part of the ___ family of viruses
molluscum contagiosum is part of the **poxvirus** family of viruses ## Footnote **dsDNA, enveloped**
39
molluscum contagiosum is spread via ____ or from \_\_\_\_
molluscum contagiosum is spread via **sexual contact** or from **fomites**
40
Molluscum contagiosum is ___ shaped with a ___ center and ___ in appearance
Molluscum contagiosum is **dome**-shaped with a **dimpled** center and **pearly** in appearance
41
describe the histology of molluscum bodies
large cells with abundant granular eosinophilic and a small peripheral nucleus
42
warts are part of the ___ family of viruses
warts are part of the **papillomaviridae** family of viruses ## Footnote **non-enveloped, dsDNA**
43
warts are caused by infection of ___ and \_\_\_\_
warts are caused by infection of **keratinocytes** and **epithelial cells**
44
warts may promote cell growth in permissive cells in \_\_\_\_
warts may promote cell growth in permissive cells in **stratum spinosum**
45
\_\_\_\_ are the most common STD worldwide
**warts** are the most common STD worldwide

Micro Term 4 (33 decks)

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