RTI IX Flashcards
Chlamydophila psittaci is a (G+ve/G-ve) and obligate _____ and causes ______
Chlamydophila psittaci is a G-ve and obligate intracellular and causes Ornithosis (Psittacosis, Parrot fever)
Chlamydophila psittaci are round with narrow _____
Chlamydophila psittaci are round with narrow periplasmic space
Chlamydophila psittaci has no _____ in the cell wall and instead contains a _____ with weak endotoxicity
Chlamydophila psittaci has no peptidoglycan in the cell wall and instead contains a lipopolysaccharide (LPS) with weak endotoxicity
____ is a major cell wall component and unique to each Chlamydophila species
Major Outer Membrane Protein (MOMP) is a major cell wall component and unique to each Chlamydophila species
Chlamydophila psittaci
small infectious EBs attach to _____, followed by _____
small infectious EBs attach to microvilli, followed by active penetration in the cell
Chlamydophila psittaci
intact _____ inhibits fusion to the ___ thus, not killing Chlamydia
intact EB outer membrane inhibits fusion to the lysosomes thus, not killing Chlamydia
Chlamydophila psittaci
6-8 hours after penetration, ____ reorganize to become _____
18-24 hrs later, the ____ divide to become ____
6-8 hours after penetration, EBs reorganize to become large metabolically active RBs
18-24 hrs later, the RBs divide to become smaller EBs again, rupturing the host cell
Chlamydophila psittaci is transmitted to humans through _____
Chlamydophila psittaci is transmitted to humans through inhalation of excreta, urine or resp. droplets of birds
Chlamydophila psittaci spreads to the ____ producing necrosis
Chlamydophila psittaci spreads to the RES of liver and kidneys producing necrosis
Chlamydophila psittaci is seeded in the lung through ____ causing lymphocytic inflammation in the _____
Chlamydophila psittaci is seeded in the lung through blood causing lymphocytic inflammation in the alveoli
Chlamydophila psittaci produces edema, thickening of the ___, infiltration of ____, necrosis and occasional hemorrhages
Chlamydophila psittaci produces edema, thickening of the alveolar walls, infiltration of macrophages, necrosis and occasional hemorrhages
name the populations at highest risk of Chlamydophila psittaci
- high risk:
- vets
- zookeepers
- pet shop owners
- employees of poultry-processing plants
describe clinical features of Chlamydophila psittaci
diagnosis of Chlamydophila psittaci is by _____
diagnosis of Chlamydophila psittaci is by serology
describe the biology of Hantavirus
- family = bunyavirus
- negative sense ssRNA virus
- RNA virus, spherical, lipid envelope with 2 major glycoproteins
name settings where exposure to rodents (thus leading to HPS) is common
- peridomestic settings:
- barns
- outbuildings
- sheds
- camping
describe the 3 clinical phases seen in HPS
in HPS, there is a generalized increase in _____ that results from ____ damage
in HPS, there is a generalized increase in capillary permeability that results from endothelial damage
injury in HPS is a consequence of _____
injury in HPS is a consequence of the host’s immunological response to viral antigens that have penetrated the endothelium
describe the diagnosis and treatment of HPS
Meliodosis (Whitemore’s disease) is an infection caused by _____
where is this disease endemic in?
Meliodosis (Whitemore’s disease) is an infection caused by Burkholderia pseudomallei
endemic regions = South Asia, SE Asia including China, northern Australia
Burkholderia pseudomallei is (G+ve/G-ve), rod-shaped, motile, aerobic
Burkholderia pseudomallei is G-ve, rod-shaped, motile, aerobic
Burkholderia pseudomallei is G-ve, rod-shaped, (motile/non-motile), aerobic
Burkholderia pseudomallei is G-ve, rod-shaped, motile, aerobic
list risk factors for Meliodosis
adults with Meliodosis primarily present with ____
while
children with Meliodosis primarily present with _____
adults with Meliodosis primarily present with pneumonia
while
children with Meliodosis primarily present with cutaneous infxns
describe the lab diagnosis of Meliodosis
Meliodosis is grown on ____ agar and has a _____ morphology
Meliodosis is grown on Ashdown’s agar and has a cauliflower-head morphology
describe what is seen on microscopy of Meliodosis
G-ve bacilli, bipolar staining
Coxiella burnietti is an obligate _____ and ____ are important reservoirs
Coxiella burnetti is an obligate intracellular bacteria (G-ve) and cattle, sheep, goats are important reservoirs
describe the 3 main acute clinical presentations of Q fever
- self-limiting flu-like illness
- pneumonia (predominant in N. America)
- hepatitis (predominant in Europe)
describe the 2 phases of Coxiella burnetti
- phase I
- highly infectious with intact LPS
- phase II
- not infectious, with truncated LPS
describe chronic Q fever and those at risk for it
sometimes present years after primary infection: culture negative endocarditis
- risk group:
- pre-existing heart defects
- pregnancy
- immunocompromised
