Skin V Flashcards
cat-scratch disease is caused by which organism?
cat-scratch disease is caused by B. henselae
in ____ patients, baciliary angiomatosis can occur
in AIDS patients, baciliary angiomatosis can occur
describe the clinical presentation of cat-scratch disease
- self-limited regional lymphadenopathy
- persistent infection of erythrocytes and endothelial cells
- can trigger proliferation of endothelial cells (vascular tumor formation)
in cat-scratch disease, there is self-limited regional _____
in cat-scratch disease, there is self-limited regional lymphadenopathy
in cat scratch disease, there is persistent infection of ___ and ___ cells
in cat scratch disease, there is persistent infection of erythrocytes and endothelial cells
the persistent infection of ____ cells in cat scratch disease can lead to ____ formation
the persistent infection of endothelial cells in cat scratch disease can lead to vascular tumor formation
upon physical examination of a patient with cat scratch disease, there is an enlarged ____
upon physical examination of a patient with cat scratch disease, there is an enlarged spleen
_____ testing is confirmatory of cat scratch disease
serologic testing is confirmatory of cat scratch disease
describe the DNA virus classification tree
describe the RNA virus classification tree
list the 2 diseases that have a centripetal rash
rubella and measles
list the 2 diseases that have a centrifugal rash
(centrifugal = fugitive = going outwards)
roseola and chickenpox
describe the viral classification of Rubeola virus
large, enveloped, (-) ssRNA
Rubeloa virus is part of the ____ family
Rubeloa virus is part of the Paramyxoviridae family
list the important envelope proteins present on Rubeola virus
-
F (fusion) protein:
- fusion to host cell membranes, viral penetration and hemolysis
-
H (hemagglutinin) protein:
- adsorption of virus to cells (NO neuraminidase)
Rubeola does NOT contain ___ as an envelope protein
Rubeola does NOT contain neuraminidase as an envelope protein
list the 4 C’s of measles
- cough
- coryza
- conjunctivitis (with photophobia)
- Coplik spots (Koplik)
____ rash appears after Koplik’s spots dissappear
maculopapular rash appears after Koplik’s spots dissappear
in measles, the rash that forms is described as (centripetal or centrifugal?)
in measles, the rash that forms is described as centripetal
in measles, there is generalized ____ and a complication is lifelong ____
in measles, there is generalized lymphadenopathy and a complication is lifelong disabilities (brain damage, blindness, deafness)
the rash seen in measles is caused by ___ damage of ____ cells
the rash seen in measles is caused by cytotoxic T cell damage of infected endothelial cells
the measles virus binds to ___ of most cells
the measles virus binds to CD46 of most cells
the measles virus infects ____ lymphocytes and dendritic cells, followed by virus transmission to ____ expressing epithelial cells (skin)
the measles virus infects CD150 lymphocytes and dendritic cells, followed by virus transmission to nectin-4 expressing epithelial cells (skin)
measles causes immunosuppression during the infection, but after resolution, there is _____
measles causes immunosuppression during the infection, but after resolution, there is lifelong immunity
prevention of measles is via a ____
prevention of measles is via a live attenuated vaccine
describe the Sketchy in relation to measles
Rubella (German measles) is part of the ___ family of viruses
Rubella (German measles) is part of the togaviridae family of viruses
enveloped +ssRNA
describe the viral composition of Rubella virus
enveloped, (+)ssRNA
the clinical presentation of rubella is very ___, but has a characteristic _____ lymphadenopathy
the clinical presentation of rubella is very mild, but has a characteristic postauricular lymphadenopathy
the rash seen in rubella spreads in a (centripetal or centrifugal?) pattern
the rash seen in rubella spreads in a centripetal pattern
describe the birth defects that can occur from Rubella
growth retardation, cataracts, deafness, congenital heart defects
I (eye) ♥ Ruby Earrings
rubella is transmitted via ____
rubella is transmitted via aerosol droplets
diagnosis of rubella is by seeing a 4x increase in ___ or ____
diagnosis of rubella is by seeing a 4x increase in IgG antibody or IgM (+)
in pregnant woman with history of contact with rubella, ___ can be recommended
it can reduce symptoms but DOES NOT eliminate the possibility of the baby developing congenital rubella syndrome
in pregnant woman with history of contact with rubella, hyperimmune globulin can be recommended
it can reduce symptoms but DOES NOT eliminate the possibility of the baby developing congenital rubella syndrome
roseola infantum virus is part of the ____ family of viruses
roseola infantum virus is part of the Herpesvirus family of viruses
enveloped dsDNA
the rash seen in roseola is described as (centripetal or centrifugal?)
the rash seen in roseola is described as centrifugal
roseola infantum can cause febrile ____
roseola infantum can cause febrile seizures
in roseola infantum, there are pink ___ and ____ surrounded by white ____
in roseola infantum, there are pink macules and papules surrounded by white halos
roseola infantum replicates in ___ and ___
roseola infantum replicates in leukocytes and salivary glands
roseola uses ___ to enter leukocytes
roseola uses CD46 protein to enter leukocytes
roseola uses ___ to enter leukocytes
roseola uses CD46 to enter leukocytes
Fifth disease is caused by ____
describe the viral composition
Fifth disease is caused by Parvovirus B19
non-enveloped, linear ssDNA icosahedral
erythema infectiosum causes a ____ appearance on the face of children
while
adults might have ____ and swelling
erythema infectiosum causes a “slapped cheek” appearance on the face of children
while
adults might have joint pain and swelling
the receptor for Fifth disease (erythema infectiosum) is the ___ located on the ____
the receptor for Fifth disease (erythema infectiosum ) is the P antigen located on the erythrocyte precursor
Fifth disease can be serious in pregnant women, where it can cause severe ___ in newborns or it can also cause ___
Fifth disease can be serious in pregnant women, where it can cause severe anemia in newborns or it can also cause miscarriage
