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RUSVM Bacteriology Gram Negatives > Shigella > Flashcards

Shigella Flashcards

1
Q

Shigella - General info

A

Enterics without capsule or flagella, gram negative, exclusive to primate large bowel

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2
Q

Shigella - Cellular products/ virulence factors

A

Adhesins (IpaD adhere M cells) - LPS O-antigen - Shiga toxin!! - SigA (IgA protease) - Pic -T3SS (IpaB/IpaC & IcsA/IcsB) - Fur, RNA polymerase

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3
Q

Shigella - Shiga toxin

A

Affects host ribosome function–> cell death

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4
Q

Shigella - Pic

A

Protein involved in intestinal colonization - Digests intestinal mucosa

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5
Q

Shigella - IpaB/IpaC

A

Formation of ruffles (cytoskeleton of hose cells) , lysis of phagocytes

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6
Q

Shigella - IcsA/IcsB

A

Intracellular spread

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7
Q

Shigella Pathogenesis

A

Ingestion–> destroy mucus & attach to M cells –> Ruffles –> intracellular movement–> tissue damage/cytokine release –> diarrhea (hemorrhagic & watery) - Hemolytic Uremic Syndrome

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8
Q

Shigella treament

A

Nursing & supportive care, antimicrobial agents, yeast compete with S. flexneri experimentally

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RUSVM Bacteriology Gram Negatives (26 decks)

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