Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

RUSVM Bacteriology Gram Negatives > Helicobacter > Flashcards

Helicobacter Flashcards

1
Q

Helicobacter Gram___? Shape?

A

Gram negative Spiral-shaped or curved

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Helicobacter Motile/Non-motile?

A

Flagellated, Motile

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Helicobacter- Original classification

A

Originally Campylobacter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Helicobacter- Associated with what signs in all species?

A

GI tract disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Helicobacter pylori Human disease pattern

A

Persistent gastritis Peptic ulcer disease Gastric adenocarcinoma (?) Gastric mucosal-associated lymphoma (?)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Helicobacter Disease range in animals

A

Asymptomatic to Gastritis to Cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Helicobacter Virulence Factors Name them

A

Flagella Urease Adhesins LPS CagPAI Vac CDT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Helicobacter Virulence Flagella

A

Motility for penetration of mucus Adherence to gastric epithelia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Helicobacter Virulence Urease

A

Hydrolyzes urea to ammonium **Ammonium neutralizes gastric acids** Associated with inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Helicobacter Virulence Adhesins

A

“Saba and Baba” SabA- Sialic acid-binding adhesin BabA - Blood group antigen-binding adhesin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Helicobacter Virulence LPS

A

Usual Endotoxin, pro-inflammatory cytokines, O-repeats=anticomplement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Helicobacter Virulence Cag PAI Codes for what?

A

Cytotoxin associated gene pathogenicity island Codes for T4SS Allows CagA protein into host cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Helicobacter Virulence Vac

A

Vacuolating Cytotoxin -Disrupts epithelial barrier -Pro-inflammatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Helicobacter Virulence CDT

A

Cytolethal Distending Toxin -Similar to that from C. jejuni

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Helicobacter - Culture conditions Aerobe/Non-aerobe

A

Microaerophilic (Not aerobic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Helicobacter - Culture conditions Optimal growth temp

A

37C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Helicobacter - Culture Colony description

A

Slow-growing, flat, non-pigmented, non-hemolytic colonies.

18
Q

Helicobacter - Culture conditions Fastidious?

A

Yes! Needs selective media

19
Q

Helicobacter - Culture conditions - Selective media

A

Vancomycin Amphotericin Trimethoprim Cefsulodin Lysed horse blood

20
Q

Helicobacter Reservoir

A

**Gastric mucus layer** Many animals

21
Q

What percentage of dogs and cats are infected with Helicobacter spp?

A

80-100%

22
Q

How many slaughtered pigs are infected with Helicobacter suis?

A

60%

23
Q

Helicobacter Transmission

A

Oral-oral Fecal-oral

24
Q

Helicobacter Zoonotic potential

A

Some evidence, not huge risk

25
Q

Helicobacter Pathogenesis

A

Not perfectly understood -Alters GI physiology w/Urease -Adjusts to gastric environment & colonizes -Chronic inflammation

26
Q

Helicobacter Pathological changes

A

Gastric & Hepatic

27
Q

Helicobacter - Pathology of Stomach

A

Hyperplasia Reduction of mucus Degeneration of glands Necrosis Variable inflammation

28
Q

Helicobacter -Pathology of liver

A

Inflammatory and necrotizing lesions

29
Q

Helicobacter - Lab Dx Smears/Stains

A

Of gastric mucosa Difficult/not impossible to identify this way

30
Q

Helicobacter- Lab diagnostic methods

A

Stained gastric mucosa smears Urease tests Culture is difficult PCR/Western Blot/ FISH

31
Q

What is the FISH diagnostic test?

A

Fluorescence in situ hybridization

32
Q

Helicobacter Treatment theory

A

Controversial, most infections subclinical -Resistance could develop quickly

33
Q

Helicobacter Treatment drugs

A

Combination therapies effective: Amoxicillin & Metronidazole Amoxicillin & clarithromycin Bismuth subsalicylate, omeprazole &/or famotidine for clinical gastric infections

34
Q

H. pylori

Catalase Pos/Neg?

A

Catalase Positive

35
Q

H. pylori

Oxidase Pos/Neg?

A

Oxidase Positive

36
Q

H. pylori

Alkaline Phosphatase pos/neg?

A

Alkaline Phosphatase Positive

37
Q

H. pylori

Indoxyl acetate pos/neg?

A

Indoxyl acetate Negative

38
Q

H. pylori

Growth at 42 C?

A

No growth at 42 C

39
Q

H. pylori

Growth in 1% glycine?

A

No growth in 1% glycine

40
Q

H. pylori

Nitrate reductase pos/neg?

A

Nitrate reductase negative

41
Q

H. pylori

Urease Pos/Neg?

A

Urease positive

RUSVM Bacteriology Gram Negatives (26 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions