Pasteurella & Mannheimia Flashcards
Family Pasteurellaceae - description
Gram negative, coccobacilli, bipolarity, facultative anaerobes, oxidase positive (difference with Enterobacteriaceae), non-motile - catalase positive - reduce nitrates & ferment carbs
Family Pasteurellaceae virulence factors - many
LPS - RTX toxin (glycine repeats & leukotoxin) -Rho activating toxin Pmt
Which two species exhibit leukotoxin?
M. haemolytica & B trehalosi
P. multicoda capsule toxin D
Atrophic rhinitis in swine, bordetella synergistic effect
RTX toxin
Bovine leukocyttes & erythrocytes - hemolysis in vitro -***Bovine Shipping Fever!
Pasteurella, Mannheimia - 3 general manifestations
Respiratory tract - septicemia - trauma associated
Pasteurella, Mannhemia pathogenesis of pneumonia
Ruminants w/predisposing condition –> commensals of URT infect lung –> intensive inflammatory response (erythrocytes, neutrophils, mononuclear cells, fibrin deposition) –> Lkt, LPSm capsule, ion scavenging occurs
Pasteurella, Mannheimia pathogenesis of atrophic rhinitis
Swine - If bordetella alone, will be self limiting infection. But: B. brochiseptica adheres–> damages epithelium (dermonecrotic toxin) –> P. multicoda toxins destroy nasal tissue –> Pmt –> destruction of bones & turbinates, chronic rhinitis (disturbed osteogenesis)
Pasteurella, Mannheimia in Cattle
Shipping Fever - Hemorrhagic septicemia - Mastitis
Shipping fever in cattle - causative species -
M. haemolytica, P. multicoda type A - B. trehalosi
Shipping fever in cattle- concurrent infections
Infectious bovine rhinotracheitis virus -Mycoplasma - Ureaplasma - Bovine respiratory syncitial virus - Parainfluenza-3
Pasteurella/ Mannheimia - Hemorrhagic septicemia in cattle - Causative species
P. multocida = REPORTABLE in USA
Pasteurella/ Mannheimia - Mastitis in cattle - causative species
M. harmolytica, P. multocida
Pasteurella/ Mannheimia - in Sheep & Goats
Septicemia - Enzootic pneumonia - Mastitis
Pasteurella/ Mannheimia - Sheep/Goat septicemia - causative species
B. trehalosis, M. harmolytica - Lambs
Pasteurella/ Mannheimia - Sheep/Goat enzootic pneumonia causative species
M. haemolytica - resembles bovine shipping fever
Pasteurella/ Mannheimia - Sheep/Goat Mastitis causative species
M. haemolytica, B. trehalosis - “Blue Bag”
Pasteurella/ Mannheimia - in Swine diseases
Atrophic rhinitis & pneumonia
Pasteurella/ Mannheimia - Swine - Atrophic rhinitis
P. multocida & Bordetella bronchis, young pigs secondary pneumonia
Pasteurella/ Mannheimia - Atropic rhinitis in Swine - virulence factors
Ammonia, Pmt, Dermonecrotic toxin
Pasteurella/ Mannheimia - Pneumonia in swine
Fibrinous pneumonia - Often follows viral infections
Pasteurella/ Mannheimia - In rabbits
Snuffles!!!! - Most important bacterial disease in rabbits - P. multocida type A, (Bordetella bronchiseptica is good DDx)
Pasteurella/ Mannheimia - in birds
Fowl Cholera - P. multocida capsule Type A & F - REPORTABLE - Very rapidly fatal
Pasteurella - Culture
VERY fastidious - Frows best on chocolate agar
Mannheimia & bibersteinia- Culture
Grow on MacConkey, or Blood agar (bov/ov blood)
Riemerella anatipestifier
“New Duck Disease”
Photobacterium damsela
Septicemia disease in fish, dolphins, humans. Halophillic rod
