sexual dysfunction

Question 1

drugs that cause sexual dysfunction

Answer 1

Alcohol

Antidepressants

Antihypertensive: Beta-blockers, clonidine, thiazides

Antipsychotics: first gen… and prolactin-raising second gen (risperidone, paliperidone)

BPH medications: finasteride, dutasteride, and silodosin (mostly retrograde ejaculation)

Question 2

PDE-5 inhibitiors

Answer 2

1st line
sildenafil, vardenafil, tadalafil, and avanafil
contra: w/ nitrates or riociguat
SE: vision loss, hearing loss, hypotension, priapism >4 hrs go to ER, FLUSHING, HEADACHE

Question 3

sildenafil

Answer 3

viagra
PAH- Revatio
- PDE-5 inhibitors

Question 4

vardenafil

Answer 4

Levitra
- PDE-5 inhibitors

Question 5

Avanafil

Answer 5

Stendra
- PDE-5 inhibitors

Question 6

Tadalafil

Answer 6

Cialis - also used for BPH
Adcirca for PAH
- PDE-5 inhibitors

Question 7

PDE-5 inhibitors dosing

Answer 7

Question 8

PDE-5 inhibitors dosing

Answer 8

50mg for viagra
10mg for cialis and levitra
100mg for stendra
reduce starting dose by 50% if
- >= 65 years
- using an alpha blocker
- using a CYP 3A4 inhibitor
- Severe renal or liver disease

Question 9

Alprostadil

Answer 9

Caverject - inject into penis
Muse- urethral pellets
- prostaglandin E1 vasodiliators

Question 10

Flibanserin

Answer 10

Addyi
contra w/ OH, hypotension, REMS

agonist of 5-HT1A and antagonist of 5-HT2A
Premenopausal female use only

Question 11

Bremelanotide

Answer 11

Vyleesi
nonselective melanocortin receptor agonist
contra: CVD
- Premenopausal females use only