compounding II: equipment, stabilty & exccipients Flashcards

1
Q

hypodermic (paranteral)
sterile compounding syringes

A

syringes are commonly used for sterile compounding to transfer drugs and additives into IV bags

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2
Q

luer lock

A

luer lock tip is designed to screw into leur lock connectors on pt’s IV access catheter or onto a needle

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3
Q

oral syringes

A

ONLY for oral use!, or NG tube but orally!

place sticker that says for oral use!
use syringe that prevents connection to IV port
oral syringe- birth color plungers/cap
clear communication of route

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4
Q

Class III (class A) torsion balance

A

have internal weights, which are used to weigh <1 gram and when weighing >1 g external weights are added to the pan

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5
Q

sensitivity requirement
- torsion balance

A

torsion balances have a sensitivity requirement (SR), most often 6mg, meaning 6mg can be added or removed before dials moves 1 division

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6
Q

minimum weighable quantity (MWQ)
- torsion balance

A

calculated based on SR and
acceptable error rate (typically 0.05 or 5%)
MWQ= SR/acceptable error rate

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7
Q

wetting agents

A

reduces surface tension between a liquid and solid to permit the substance to more easily spread
levigating agents can be referred to as wetting agents

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8
Q

emulsifiers

A

emulsion, two or more liquids which are not able to blend together (immiscible)
emulsifiers help keep the liquid droplets dispersed throughout the liquid vehicle
prevent to liquid from separating

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9
Q

suspending agents

A

solid dispersed in liquid, suspending agents help keep solid particles from settling- don’t keep this for long so suspension must be shaken to redisperse

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10
Q

levigating agent

A

make particles smaler
such as glycerin or mineral oil aid in the grinding. mineral oil commonly used for levigating for lipophilic compounds. glycerin for aqueous

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11
Q

foaming agents

A

lower surface tension of water
- ex detergents
non-sterile: anti-foaming agents simethicone

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12
Q

glycol & gel used as surfactants and delivery vehicles

A

polyethylene glycol (PEG) and poloxamer, or P in PLO are the delivery vehicles and surfactants

P- pluronic
L- lecithin
O- organogel

hydrophilic and hydrophobic-
poloxamer gel- topical drug delivery useful

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13
Q

hydrophilic-lipophilic balance (HLB)

A

HLB #
0-20 scale
<10: more lipid-soluble water-in-oil (w/o) emulsions
>10: more water-soluble oil-in-water (o/w) emulsions

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14
Q

process to prevent drug degradation

A

excipients- buffer to retain pH, preservatives
Ligh protect
packages- seal tightly to keep moister out
proper storage

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15
Q

Binders

A

table content to stick together, provide stability and strength
ex: acacia, starch paste, sucrose syrup…

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16
Q

diluents and fillers

A

diluents (make something more dilute) and filler add size to small dosages

tab/capsules: lactose, starches, Ca sal, cellulose
liquid: water, glycerin, OH
topical: petrolatum

17
Q

disintegrants

A

break up tab faster after oral admin
alginic acid, cellulose, polacrilin potassium, starches

18
Q

lubricants

A

improve powder flowability
mag stearate, PEG, glycerin

19
Q

preservatives

A

do not use in nonates
prevent or slow grow of microbes
chlorhexidine, povidone-iodine, sodium benzoate, sorbic acid, methyl/ethyl/ propyl parabens

20
Q

poloxamer gel “thermo reversible”
poloxamer (pluronic) lecithin organonel (PLO) gel

A

liquid at cold temp and gel at room.
both water and oil loving

21
Q

alcohol avoid in

A

children

22
Q

aspartame (phenylalanine) avoid in

A

avoid in PKU

23
Q

preservatives avoid in

A

neonates

24
Q

xylitol avoid in

A

dogs, cause hypoglycemia and liver damage

25
Q

stainless- spatula should not be used when compounding what?

A

steel spatula or plastic spatula are generally used, but steel spatula should not be used when compounding metal ions