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oncology II Flashcards

1
Q

selective estrogen receptor modulatorsm

A
  • SERMs
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2
Q

tamoxifen

A

soltamox
- SERMs

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3
Q

tamoxifen info:

A
  • increase risk of uterine or endometrial cancer
  • QT prolongations
  • increase risk of thromboembolic event
  • hypo K and Mg
  • hot flashes/ night sweats etc.
  • decreases bone density… supplement w/ Ca and vitamin D
  • teratogenic
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4
Q

fulvestrant

A

Faslodex
IM only
- selective estrogen receptor degrader (SERD)

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5
Q

anastrozole

A

Arimidex
- aromatase inhibitor

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6
Q

letrozole

A

Femara
- aromatase inhibitor

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7
Q

exemestane

A

Aromasin
- aromatase inhibitor

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8
Q

trastuzumab

A

Herceptin
need HER2 positive
- mab

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9
Q

gonadotropin-releasing hormone agonist

A

GnRH agonists
also known as luteinizing hormone-releasing hormone (LHRH) agonists, they reduce testosterone through a negative feedback mechanism, causing an initial surge in test followed by gradual reduction

  • will cause decrease in bone density, sue w/ Ca and vitamin D
  • tumor flare: prevent w/ concurrent sue of antiandrogent
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10
Q

leuprolide

A

Lupron Depot
- GnRH agonists

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11
Q

Goserelin

A

Zoladex
- GnRH agonists

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12
Q

GnRH antagonists

A

block GnRH directly causing a rapid decrease in testosterone productions

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13
Q

degarelix

A

firmagon
- GnRH antagonists

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14
Q

Relugolix

A

Orgovyx
- GnRH antagonists

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15
Q

bicalutamide

A

Casodex
- first gen, antiandrogens

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16
Q

Nilutamide

A

Niladron
- night blindness, DISULFIRAM reactions (avoid OH)
- first gen, antiandrogens

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17
Q

apalutamide

A

erleada
- seizures risk and QT prolongation
- second gen, antiandrogens

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18
Q

darolutamide

A

Nabeqa
- neutropenia
- second gen, antiandrogens

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19
Q

enzalutamide

A

Xtandi
- seizures risk
- second gen, antiandrogens

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20
Q

Abiraterone

A

Zytiga
- androgen biosynthesis inhibitors

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21
Q

BSA (m^2)

A

= sq root of ((Ht(cm) x Wt(kg))/ 3600)

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22
Q

Cyclophosphamide
Ifosfamide

A

Ifex
- dispensed w/ Mesna
- alkylating agents

23
Q

carmustine

A

BiCNU, Gliadel Wafer)
- alkylating agents

24
Q

Lomustine

A

Gleostine
- alkylating agents

25
Busulfan
Myleran - alkylating agents
26
Cisplatin
- platinum-based compounds
27
Carboplatin
- platinum-based compounds
28
oxaliplatin
- platinum-based compounds
29
Doxorubicin
adriamycin keep track of lifetime accumulation of dose 450-550 max, totect when >300 cumulative dose - anthracyclines
30
Mitoxantrone
- anthracyclines
31
Irinotecan
Camptosar - topoisomerase I inhibitors
32
Bleomycin
- topoisomerase II inhibitors
33
etoposide
- topoisomerase II inhibitors
34
vincristine
- vinca alkaloids
35
vinblastine
- vinca alkaloids
36
paclitaxel
- taxanes
37
docetaxel
- taxanes
38
fluorouracil
"5-FU" - pyrimidine analog antimetabolites
39
capecitabine
Xeloda - pyrimidine analog antimetabolites
40
methotrexate
trexall, otrexup, rasuva - folate antimetabolites
41
pemetrexed
alimta - folate antimetabolites
42
pralatrexate
folotyn - folate antimetabolites
43
in autoimmune disease folate
- dose of methotrexate is much lower - folic acid is recommend prophylactically to reduce SE - leucovorin is NOT used unless the pt does not respond to folic acid
44
in oncological disease folate
- dose of methotrexate is much higher - rescue the pt from high- dose tox, a reduced form of folate must be started after methotrexate has a chance to kill the chance cancer cells. Leucovorin or levoleucovorin is given - regular folate is not effective in rescue - folate is sued w/ pemetrexed and pralatrexate to reduce SE
45
ci
circulatory system - moncolonal antiboides
46
tu
tumor - moncolonal antiboides
47
li
immune system - moncolonal antiboides
48
bevacizumab
Avastin impairs wound healing: do not administer 28 days before or after surgery - vascular endothelial growth (VEGF) inhibitors
49
trastuzumab
Herceptin need HER2 positive before start monitor LVEF - human epidermal growth factor 2 (HER2) inhibitor
50
cetuximab
Erbitux - epidermal growth factor preceptor (EGFR) inhibitors
51
rituximab
Rituxan - leukocyte cluster of differentiation (CD) antigens inhibitors
52
pembrolizumab
keytruda - programmed death receiptor-1 (PD-1) inhibitor
53
ipilimumab
yervoy - CTLA-4 inhibitor cytotoxic T-lymphocyte antigen-4
54
imatinib
gleevec - tyrosin kinase inhibitors

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