contraception & Infertility Flashcards

1
Q

ovulation summary

A
  • The surge in estrogen causes luteinizing hormone (LH) and FSH (follicular stimulating hormone)
  • LH surge triggers ovulation 24 -36 hours
  • Luteal the start of ovulations begins and which lasts till 14 days, progesterone is dominant in this phase
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2
Q

ovulation kits

A

measure LH, first urine, if LH is present, ovulation will occur in 24-36 hers, best time for intercourse to conceive

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3
Q

prego

A

human chorionic gonadotropin (hCG) positive
generally best to measure w/ prego test first urine when levels would be the highest

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4
Q

folic acid

A

400mcg DFE to 600mcg DFE (which is equivilant to 360mcg RDA)

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5
Q

return to fertility

A

most contraceptions you return to fertility immediately, but medroxyprogesterone injection

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6
Q

caya

A

diaphragm, single size and does not require fitting (some do require prescription for fitting)

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7
Q

oil-based lubricants

A

never recommend oil-based lubricant for use w/ a latex or non-latex synthetic condom. ONLY recommend water or silicon-based lubricants

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8
Q

Phexxi

A

prescription-only vaginal gel that maintains an acidic pH (3.5-4.5)
spermicide OTC, but keep in mind, higher risk of STDs, UTIs, not a good option..

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9
Q

hormonal contraceptives

A

inhibit the production of FSH and LH, which prevents ovulation
They also alter cervical mucus, which inhibits the sperm from penetrating the egg

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10
Q

progestin-only options

A

pill, injectable, implantation, and IUD

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11
Q

estrogen/progestin products

A

pill, patch, and vaginal ring
oral products are called COCs- combination oral contractacpetions

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12
Q

progestin is what in most COCs products

A

norethindrone, levonorgestrol, drospirenone

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13
Q

monophasic COCs

A

same dose of estrogen and progestin throughout the pill pack

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14
Q

biphasic, triphasic, and quadriphasic COCs

A

mimic the estrogen and progestin levels during the menstrual cycle

bi, tri, quad- represents the number of times the hormones changes

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15
Q

drospirenone

A

potassium-sparing diuretics

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16
Q

elagolix

A

orilissa- is FDA-approved for moderate to severe pain associated w/ endometriosis

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17
Q

heavy menstrual bleeding

A

menorrhagia
COC Natazia and the levonorgestrel-releasing IUD Mirena are indicated

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18
Q

lysteda

A

an oral formulation of tranexamic acid (antifibrinolytic) is a non-hormonal tx for menorrhagia

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19
Q

POPs- progestin-only pills

A

suppress ovulation
and thicken the cervical mucus to inhibit sperm penetration and thinning the endometrium

primarily used in breastfeeding women cause estrogen decrease milk production, and increase thrombosis risk

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20
Q

POPs adherence

A

must be taken within 3 hours of the scheduled time

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21
Q

migraines w/ aura

A

estrogen CAN NOT be used, increased risk of stroke, POPs are used

22
Q

Depo-prevera, prevera

A

medroxyprogesterone
IM, every 3 months
progesterone only- suppressed ovulation, thickens the cervical mucus and causes thinning of the endometrium
About half of users will be amenorrheic (no menses) after 1 year of use..

23
Q

extended-cycle COCs

A

periods every 3 months

24
Q

“Lo”

A

means <=35mcg of estrogen
ex: Loestrin

25
"Fe"
iron supplement included ex: Loestrin Fe
26
"24"
shorter placebo time 24 active, 4 placebo= 28 day cycle
27
monophasic formulations
Junel Fe 1/20 (1mg norethindrone, 20mcg EE) Microgestin Fe 1/20 Sprintec 28 Loestrin 1/20, Loestrin 24 Fe, Lo Leostrin Fe Yasmin 28, Yaz
28
biphasic, triphasic formulation
ortho tri-cyclen lo, tri-sprintec
29
quadriphasic formulation
Natazia
30
Extended Cycle Formulation
Seasonique
31
drospirenone-containing formulation
Yasmin 28, yaz
32
continuous formulation
amethyst no inactive pills
33
patch
xulane, twirla
34
progestin-only
Errin, Camila, Nora-Be
35
ACHES
severe & rare AE of estrogen A-abdominal (stomach) pain that is severe C- chest pain H- headaches E- eye problems S- swelling or sudden leg pain
36
box warning all estrogen-containing products (pills, rings, patch)
do not use in women >35 old who smoke due to risk of serious cardiovascular events
37
box warning estrogen + progestin transdermal patch
increased risk of DVT/PE compared to COCs
38
box warning depo-Provera
loss of bone mineral density w/long-term use
39
box warning do not use estrogen w/ these conditions
history of DVT/PE, stroke, CAD... etc history of breast, ovarian, or liver cancer severe headaches or migraines w/ aura
40
what decreases hormonal contraception efficacy
- antibiotics (inducers- rifampin, rifabutin...) - aniconvulsants (carbamazepine....) - st. john's wort - smoking tobacco - ritonavir - bosentan - mycophenolate
41
liver tox
mavyret and viekira pack can not be used w/ any ethinyl estradiol due to the risk of liver tox.
42
COCs 1 late or missed pill <48hrs since the last dose
- take the missed pill as soon as possible and take the next dose on schedule even if its 2 pills in 1 day
43
COCs 2 missed pills (>= 48hrs since last dose)
- take the missed pill as soon as possible and take the next dose on schedule even if its 2 pills in 1 day ---> Consider emergency contraception if unprotected sex in last 5 days if week 3 - Omit hormone-free week: start the next pack of pills right after finishing current pack
44
POPs if >3 hrs past scheduled time
back up contraception required x 48hrs ---> Consider emergency contraception if unprotected sex in last 5 days
45
IUD
Mirena (FDA approved for heavy menstural bleeding) Skyla Kyeena Liletta this is progestin levonorgestrel
46
copper-T
paraguard EC/ and regular birth control not hormonal
47
Copper IUD - EC
within 5 days paragard
48
Ulipristal
Ella ASAP, within 5 days prescription needed chemical causing of mifepristone... so there is a controversy but nothing is proven
49
Levonorgestrel
Plan B or generic ASAP, within 3 days OTC
50
infertility drugs act like
try to increase LH/FSH -->ovulation Clomiphene acts as estrogen to increase LH/FSH Aromatase inhibitors suppress estrogen to increase FSH gonadotropin drugs acts as LH, FSH, or hCG