SERONEGATIVE SPONDYLOARTHROPATHIES I Flashcards
SAs are RF positive or negative?
negative
what are the spondyloarthropathies?
axial spondyloarthritis
- ankylosing spondylitis
- nonradiographic axial spondyloarthritis
reative arthritis
psoriatic arthritis
arthritis associated with GI disease
clinical features
inflammation of axial spine involvement
asymmetric peripheral arthritis
dactylitis
enthesitis
absence RF
HLA-B27
extra articular manifestation
the sacroiliac joint is affected in a condition called?
sacroillitis
swelling of the entire digit, sausage digits
dactylitis
inflammation at bony insertions of tendons, ligaments, and fascia occurring peripherally and in the spine
locations?
enthesitis
heels, at insertion of:
achilles tendon
plantar fascial ligament
*also spurs
gene located in spondyloarthropathies and located on this chromosome
HLA-B27
chromosome 6
this gene aids in determining immunity and in self recognition cells and tissues
HLA-B27
inflammation of the middle layer of the eye consisting of the iris, ciliary body, and the choroid
4 types
symptoms
uveitis
anterior, intermediate, posterior, diffuse
anterior
-pain, redness, light sensitivity, decreased visual acuity
intermediate/posterior
-painless, floaters, blurred vision
diffuse-mixed symptoms
name this of SA:
a chronic inflammatory disease of the axial skeleton, spine and sacroiliac joints
axial spondyloarthritis
ankylos means
spondylos means
crooked or bent
spinal vertebra
pathogensis of ankylosing spondylitis
precise cause unclear but limited with HLA-B27
genetics
epidemiology of AS?
HLA-B27
genetics
males more affected
20-30 years of age
how does AS present?
low back pain chest pain enthesitis sacrolitis dactylitis extra-axial decreased spinal mobility synovitis peripheral Arthritis loss of normal posture
what are the extra articular manifestations of AS?
fatigue, weight loss
acute anterior uveitis
CV disease
pulmonary disease
neuro involvment
renal pblms
osteoporosis
IBS
