RA Flashcards
chronic systemic autoimmune inflammatory disease characterized by joint swelling, joint tenderness, destruction of synovial joints leading to the severe disability and mortality
RA
age range?
45-65 years
what joints are affected in 90% of patients?
what else
so most common joints?
MTJ
midfoot, ankle, STJ
MCP
PIP
MTP
wrist
risk factors?
genetic link gender tobacco bacteria virus
primary site of inflammation in RA?
synovium
increases depth of synovial lining with mononuclear cells infiltrate sub lining- edema, blood vessel proliferation, increase in tissue volume
synovium
synovial membrane derived villus projections protrude into the joint cavity which invade cartilage and bone, results in destruction of cartilage and bone
pannus
name this deformity
hyperextension of the PIPJ of the finger and flexion of the DIPJ
swan neck deformity
name this deformity
flexion of the PIPJ and extension of the DIPJ
boutonniere deformity
name this deformity
subcutaneous, central area of necrosis rimmed by palisading fibroblasts surrounded by collagen capsule and perivascular inflammatory cells
rheumatoid nodules
name this deformity
deviation and subluxations occur here
ulna
what are the diseases associated with RA?
cervical spine
felty’s syndrome
sjogrens syndrome
raymauds phenomenon
rheumatoid arthritis can be systemic?
yes
labs and diagnostic testing?
other ones?
CBC with diff positive RF factor positive ACPA ANA, SS-A. SS-B Uric Acid-WNL synovial fluid analysis straight up straw colored
ESR CRP radiograph MRI ultrasound
the RF is what kind of antibody?
IgM