RHEUMATOID ARTHRITIS TERMS Flashcards
Chronic systemic autoimmune inflammatory disease
characterized by joint swelling, joint tenderness, destruction
of synovial joints leading to the severe disability and
mortality
RA
Primary site of inflammation in RA
Increases depth of synovial lining while mononuclear cells infiltrate sub-lining edema,
blood vessel proliferation, and increase in tissue
volume
Synovium
synovial membrane derived villous projections protrude into the joint cavity which
invade cartilage and bone. This results in destruction of cartilage and bone.
Pannus
name this deformity
Hyperextension of the PIPJ of the finger and Flexion of the
DIPJ
Swan-Neck deformity
name this deformity
Flexion of the PIPJ and Extension of the DIPJ
Boutonniere deformity
name this deformity
subcutaneous, central area of necrosis rimmed by palisading
fibroblasts surrounded by collagen capsule and perivascular inflammatory cells
Rheumatoid nodules
C1/C2 subluxation, prior to anesthesia may need radiograph of cervical area
Cervical spine
RA/Splenomegaly/Neutropenia
Felty’s Syndrome
RA/Dry eyes(keratoconjuctivits sicca)/Dry mouth
Sjogren Syndrome
this phenom can be seen with RA
a medical condition in which spasm of arteries cause episodes of reduced blood flow
Raynaud’s Phenomenon
• Antibody that is produced by the immune system against CCPs
• May be positive in early disease approximately 50-60% of patients, can aid in
differentiation of positive RA test in other diseases
• Increased: RA (specificity > 95%, sensitivity 80%), rare false-positives with
hepatitis and autoimmune thyroid disease
what is it?
ACPA/Anti-CCP (cyclic citrullinated peptide)
• Useful screening test in patients with symptoms suggesting collagen–vascular
disease. 5% of healthy people can have positive test.
• Positive: SLE, drug-induced lupus-like syndromes (eg, from procainamide, hydralazine,
isoniazid), scleroderma, MCTD, RA, polymyositis, juvenile RA (5–20%).
what is it?
Antinuclear Antibody
