OTHER ARTHOLOGIES

Question 1

A chronic systemic autoimmune disorder where the immune system is activated recurrently contributing to inflammation and tissue damage which may affect multiple organ systems

Answer 1

lupus

Question 2

organ systems involved in lupus?

Answer 2

skin
MSK
renal
hematologic
CNS
pulmonary 
CV
GI
ocular

Question 3

highest incidence of SLE found in?

Answer 3

african americans
asian americans
hispanic american

Question 4

etiology SLE?

Answer 4

genetics
hormonal
environmental factors

Question 5

what are the constitutional symptoms of SLE?

cutaneous manifestations?

Answer 5

fatigue
fever
myalgia
weight loss/weight gain

lupus specific lesions
-acute, subacute, chronic cutaneous erythematous

Question 6

name this type of lupus?

localized or generalized

hallmark is butterfly rash to malar region

macular or maculopapular erythema

in severe form, widespread bullae that heal without scarring

Answer 6

acute cutaneous lupus erythematous

Question 7

name this type of lupus?

non scarring, photosensitive lesions

last for weeks to months and heals without scarring

predilection for back, neck and shoulders

associated with anti SS-A/Ro antibody

drug induced

• terbinafine
• ACE I
• HCTZ
• Ca Channel blockers

Answer 7

subacute cutaneous lupus erythematous

Question 8

papulosquamous lesion

annular polycyclic lesion

indicates?

Answer 8

subacute cutaneous lupus erythematous

Question 9

name this type of lupus?

variety of subtypes of photosensitive lesions that can lead to skin atrophy and scar

last for months or years

most common subtype-discoid lupus

other subtypes include: lupus panniculitis, chilblain lupus, mucosal DLE

Answer 9

chronic cutaneous lupus erythematous

Question 10

discoid lupus

lupus non specific skin lesions
-vasculitis, bullous lesions

cutaneous manifestations

• photosensitivity
• alopecia
• mucosal ulcers

Answer 10

chronic cutaneous lupus erythematous

Question 11

jaccouds arthritis is often indicated in SLE?

Answer 11

yes

Question 12

SLE is multisystemic and involves renal, neuropsychiatric, and also pulmonary, GI, ocular, and CV, T/F?

Answer 12

T

Question 13

clinical symptoms in SLE?

Answer 13

constitutional symptoms

butterfly rash

hair loss

raynauds phenom

joint pain/swelling

LE edema

Question 14

SLE lab diagnostics?

Answer 14

ANA

Anti- DS DNA

antiphospholipid antibodies

CBC w/ dif

creatinine

UA

RF and Anti-CCP to rule out

Question 15

SLE differential diagnosis?

Answer 15

RA

mixed CT diseases

systemic sclerosis

sjogren’s syndrome

vasculitis

fibromyalgia

viral infections

Question 16

SLE treatment?

Answer 16

RA consult

multifactorial so comb of therapy indicated

hydroxychloroquine for flaring seen in arthralgias, NSAIDs, then methotrexate and DMARDs next

glucocorticoids

lifestyle mods like limiting smoking and drinking

Question 17

A disease that involves autoimmunity, inflammation, functional and structural alterations in small blood vessels and widespread interstitial and vascular fibrosis affecting the skin
and internal organs.

used to describe the presence of hardened, thickened skin.

Answer 17

Scleroderma

Question 18

etiology of scleroderma?

Answer 18

combination of genetics,

environmental factors, drugs, and viruses

Question 19

risk factors for systemic sclerosis?

Answer 19

genetics with family hx
exposure to EBV or CMVor parvovirus
petroleum based products
drugs like bleomycin

Question 20

epidemiology of systemic sclerosis?

Answer 20

rare disease
100 to 300 cases per million pop
higher incidence in US
african americans
women
35-50
higher mortality rate

Question 21

subsets of systemic sclerosis?

Answer 21

limited cutaneous systemic sclerosis
diffuse cutaneous systemic sclerosis
systemic sclerosis sine scleroderma
systemic sclerosis with overlap syndrome

Question 22

name this type of systemic sclerosis?

milder symptoms
puffy fingers distal to MCPJs but develops also in the elbows/knees and face/neck
trunk spread
raynauds phenom
less severe internal organ involvement
CREST syndrome

Answer 22

limited cutaneous systemic sclerosis

Question 23

what is CREST syndrome?

Answer 23

calcinosis
raynauds phenom
esophageal dysfunction
sclerodactyly
telangiectasis

Question 24

raymauds phenom?

Answer 24

paroxysmal bilateral digital arterial vasospasm

• primary
• sceondary

cold stress induced

females
younger age group
fx