September 30, 2015 - T Cell Physiology Flashcards

1
Q

Variable Region

A

Binds the antigen.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

T Cell Selection

A

Occurs in the Thymus.

Very few cells actually “graduate” the thymus. TCRs that can’t interact with self MHC molecules are destroyed, and TCRs that are too attracted to self MHC are destroyed.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Subsets of CD4 T Cells

A

TH1 - Intracellular microorganisms

TH2 - Parasitic infections

TH17 - Extracellular bacteria and fungi

Treg - Tolerance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

TH1 Cells

A

Important for stimulating macrophages and stimulating antibody production.

Important for the ingestion and killing of INTRAcellular microbes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

TH2 Cells

A

Stimulates the production of IgE antibodies as well as activating eosinophils.

Helpful for fighting helminth parasites.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

TH17 Cells

A

Capable of recruiting neutrophils and causing inflammation. Also are implicated for their role in autoimmune diseases.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Treg Cells

A

Immunosuppressive cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Central Tolerance

A

Learned in Thymus.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Peripheral Tolerance

A

When mature T cells recognize self-antigens in peripheral tissues (that weren’t in the Thymus). Inactivation of the cell occurs normally.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Autoimmunity

A

The loss of immunological tolerance.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly