October 8, 2015 - SG - Leukocytosis

Question 1

Orderly vs Disorderly

Answer 1

Orderly implies that there are more “mature” cells than immature cells.

Disorderly is the other way around.

Question 2

Philadelphia Chromosome

Answer 2

A fusion of chromosome 9 and 22.

Diagnostic of CML

Question 3

Imatinib

Answer 3

Also known as Gleevac

Is a 1st generation tyrosine-kinase inhibitor used in the treatment of cancers, most notably Philadelphia chromosome-positive (Ph⁺) CML.

Question 4

Gleevac

Answer 4

Also known as Inatinib

1st generation TK inhibitor

Question 5

Leukamoid Reaction

Answer 5

Is an increased WBC count with a physiological response to stress or infection. This can mimic leukemia. This can be either lymphoid or myeloid.

However, some differences are that it will be orderly, have normal levels of basophils and eosinophils, not have blasts, always have thrombocytosis, usually have no splenomegaly, and not have Ph Chromosome.

Question 6

Affects of Prednisone

Answer 6

Antibody suppression

Impaired phagocytosis

Lymphopenia

Monocytopenia

Question 7

Elevated Eosinophils

Answer 7

They can be really high in the presence of parasites and allergies.