August 10, 2015 - Laboratory Session 1

Question 1

Gastritis

Answer 1

Inflammation of the stomach. Characterized by erythema (redness), edema, with the possibility of punctate hemorrhages.

Question 2

Benign Peptic Ulcer

Answer 2

Question 3

Features of Benign Peptic Ulcers

Answer 3

Gross-level

• Sharp, punched out borders
• Mucosal margin level with surrounding margin

Microscopic-level

• Inflammation
• Sharp borders
• No malignant cells

Question 4

Features of Malignant Ulcers

Answer 4

Gross-level

• Heaped up margins

Micrscopic-level

• Malignant cells

Question 5

Types of Gastric Adenocarcinoma

Answer 5

Intestinal and diffuse.

Intestinal

• Tumor cells form glands
• Tumor forms mass/ulcer

Diffuse

• Discohesive signet ring cells
• Intense desmoplastic response creates a thickened, non-compliant stomach wall.

Question 6

Gastric Adenocarcinoma - Intestinal Histology

Answer 6

Tumor cells are organized into glands.

Question 7

Gastric Adenocarcinoma - Diffuse Histology

Answer 7

Discohesive malignant cells percolating through stoma.

Question 8

Histologic Features of H. pylori Gastritis

Answer 8

1. H. pylori organisms are present
2. Intraepiuthelial neutrophils
3. Subepithelial plasma cells with lymphoid aggregates