October 9, 2015 - Genetics II

Question 1

Genetic Targets in Cancer

Answer 1

1. Oncogenes
2. Tumour suppressor genes
3. DNA repair genes

Question 2

Oncogene

Answer 2

Mutated form of a proto-oncogene

Gain of function mutation

Question 3

Tumor Suppressor Genes

Answer 3

Exert negative effects on regulation of the cell cycle

Loss of function mutations

Question 4

DNA Repair Genes

Answer 4

Act as the genomic caretakers

Chromosome instability syndromes result

Question 5

Fanconi Anemia

Answer 5

Autosomal recessive and leads to a predisoposition to cancers.

Presents with anemia and pancytopenia.