schizophrenia Flashcards

•Describe positive and negative symptoms seen in schizophrenia •Differentiate between good and bad prognostic signs in schizophrenia •List the most commonly reported neuropsychological deficits (dorsolateral prefrontal cortex and related executive function) and imaging findings (enlarged ventricles) •Differentiate between schizophreniform disorder, brief psychotic disorder, schizoaffective disorders, shared psychotic disorder and schizophrenia (see additional handout from Dr. Spollen

1
Q

characteristic sx of schizophrenia

A

delusions, hallucinations, odd behavior, lauguage disturbance, normal memory and cognition

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2
Q

delusions in schizophrenia

A

false, unreasonable beliefs
often elaborate and cultural
not culturally bound beliefs
often paranoid

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3
Q

typical hallucinations in schizophrenia

A

auditory (voices)

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4
Q

neologism

A

made up words

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5
Q

echolalia

A

repeating words

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6
Q

incidence of schizophrenia worldwide

A

1%

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7
Q

age of schizophrenia onset in males

A

15-25

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8
Q

age of schizophrenia onset in females

A

20-30

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9
Q

indocators of good progress in schizophrenia (5)

A

doing well before illness
abrupt onset
later onset
prominent confusion
FMX of mood disorder

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10
Q

indicators of poor progress in schizophrenia

A

gradual onset
withdrawn, odd before illness
early onset
FMX of psychosis

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11
Q

environmental potential cause of schizophrenia

A

neuroimmunovirologia

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12
Q

non genetic risk factors for schizophrenia

A

season of birth
delivery complications
advanced parental age
drug use

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13
Q

risk of schizophrenia if a parent has it

A

10%

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14
Q

risk of schizophrenia if both parents have it

A

50%

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15
Q

risk of schizophrenia if an identical twin has it

A

50%

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16
Q

dx criteria of schizophrenia

A

2 or more sx each active for one month
continuous signs of disturbance for 6 months with at least 1 month of active sx

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17
Q

sx of schizophrenia criteria

A

hallucinations
delusions
disorganized speech
catatonia or grossly disorganized behavior
negative sx

18
Q

negative sx of schizophrenia

A

affective flattening, alogia, avolition

19
Q

subtypes of schizophrenia

A

paranoid
catatonic
disorganized
undifferentiated

20
Q

sx of paranoid schizophrenia

A

prominent delusions
later onset
high functioning
logical and coherent laungauge

21
Q

type of schizophrenia that responds to ECT

A

catatonic

22
Q

most common subtype of schizophrenia

A

undifferentiated

23
Q

positive sx of schizophrenia

A

delusions, hallucinations

24
Q

DDX of schizophrenia

A

cocaine/stimulant/PCP intox
organic brain disease
bipolar, schizoaffective, delusional disorder

25
Q

schizoaffective disorder description

A

schizophrenia +prominent mood disorders at times

26
Q

way to distinguish psychosis in schizophrenia from bipolar

A

bipolar is not chronic psychosis and more likely to normalize

27
Q

difference between deulsional disorder and schizophrenia

A

prominent delusions w/o hallucinations or lauguage disturbance
usually starts later in life
uncommon
often paranoid

28
Q

meets schizophrenia sx criteria but only lasting one month

A

brief psychotic disorder

29
Q

meets schizophrenia sx but less than 6 months

A

schizophremiform disorder

30
Q

physical brain findings in schizophrenia

A

increased ventricles
shrunken thalmus
frontal lobe involvement

31
Q

neurotransmitter in schizophrenia

A

dopamine (too much)

32
Q

micropathology in schizophrenia

A

fewer, compact cortical neurons
disoranized cortex layers
less dendritic arborization
less glia

33
Q

almost 100% of schizophrenics use this drug

A

nicotine

34
Q

comorbidities in schizophrenia

A

smoking related illnesses, diabetes, suicide

35
Q

low potency 1st gen antipsychotic

A

chorpromazine

36
Q

high potency 1st gen antipsychotic

A

haloperidol

37
Q

second gen antipsychotics

A

olanzapine, aripprazole

38
Q

SE of olanzapine

A

weight gain, diabetes, sedation

39
Q

SE of clozapine

A

agranulocytosis, seziures, weight gain

40
Q

current “stand-out” antipsychotic for schizophrenia

A

clozapine

41
Q

lobe involved in positive schizophrenia sx

A

limbic

42
Q

lobe involved in negative schizophrenia sx

A

frontal