CNS Neoplasms Flashcards
1. Identify the general categories of neoplasms based on their histogenesis: Gliomas, Meningioma, Medulloblastoma / PNET, lymphoma, Metastatic neoplasms 2. Describe how the WHO grading system works and what the different categories mean 3. Compare and contrast pathologic features of selected neoplasms (#1) with their clinical behavior \ outcome 4. Describe how different pathologic diagnoses impacts management 5. Identify the typical presentations of most common neoplasms (#1)
tumors of brain parenchyma
glioma
3 types of glioma
astrocytoma, oligodendroglioma, ependynoma
types of astrocytoma
diffuse and pilcytoma
acount for 80% of adult astrocytomas
diffuse
presenting sx of diffuse astrocytoma
seziures, headaches, focal neuro deficit
worst type of diffuse astrocytoma
glioblastoma
mutation in glioblastoma
loss of function in p53 and Rb and gain of function in oncogenic PI3K
immnostaining for mutated form of ____ can diagnose low staining astrocytoma
IDH1
characterized by mild to moderate increase in umber of glial cell nuclia, fine glial fibrillary acidic proteinpositive astrocytic processes
well-differentiated astrocytomas
cystic tumor with a mural nodule
pilocytic astrocytoma
tumor with necrosis and vascular proliferation
glioblastoma
gelatninous graymasses that may show cysts, focal hemorrage and calcification
oigodendrogliomas
common childhood tumor presenting in the cerebellum
medulloblastomas
benign tumors of the meningies
meningioma
