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CNS I > AP/AD side effects > Flashcards

AP/AD side effects Flashcards

1
Q

TCAs in general

A

sedation, anticholernergic, prolonged QT, weight gain

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2
Q

MOAis in general

A

hypertensive/serotonin crisis, orthostatic hypotension, sexual dyfunction, weight gain

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3
Q

SSRIs in general

A

agitation, insomnia, sexual dysfunction,

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4
Q

sertraline specific

A

nausea

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5
Q

paroxetine specific

A

sedation, bad withdrawal

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6
Q

citalopram specific

A

prolonged QT, interacts with PPI in elderly

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7
Q

SNRI in general

A

noradrenergic, nausea on start, withdrawal syndrome

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8
Q

venlafaxine specific

A

dose dependant hypertension

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9
Q

nefazodone specific

A

small risk of liver dysfunction

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10
Q

trazodone specific

A

sedation, priapism

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11
Q

bupropion

A

stimulant, dose related risk of seizures, risk of eating disorders

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12
Q

mirtzapine

A

very sedating, weight gain

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13
Q

paraxone/ fluoxetine can reduce effect of

A

makes less effective: tamoxifen, codine (any prodrugs)

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14
Q

fluvoxamine can increase effect of

A

caffiene, clozapine

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15
Q

SSRI/SNRI can cause bleeding with

A

warfarin, NSAIDS, aspirin

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16
Q

typical APs in general

A

extrapyrimidal SE, endocrine disturbances, edema and weight gain, sedation, convulsions in epileptics,

17
Q

chlorpromazine specific

A

sedation, autonomic sx worse

18
Q

thioridazine

A

sedation, autonomic sx worse

19
Q

loxapine

A

higher extrapyramidal effects

20
Q

molindone

A

higher sedation and extrapyramidal

21
Q

thiothixene

A

high extrapyramidal effects

22
Q

fluphenazone

A

very high high extrapyramidal effects

23
Q

haldol

A

very high extrapyramidal effects

24
Q

typical ADs interact with

A

increase effects of CNS depressants, reduce L-Dopa, increase anticholenergic effects of TCA

25
Q

atypical APs in general

A

possible diabetes, weight gain, extrapyrimidal, endocrine

26
Q

cloazpine

A

AGRANULOCYTOSIS, de novo seizures, salaivation,

27
Q

risperidone/paliperadone

A

asthenia, drowsiness, high prolactin, most likely of 2AP to cause extrapyramidal SE

28
Q

olanzapine

A

extrapyramidal SE, posterural hypotension, constipation and weight gain

29
Q

quetapine

A

BLACK BOX FOR QTc, tradive dyskinesias

30
Q

ziprasidone

A

slight QTc, weight loss, transient prolactin

31
Q

ariripirazole

A

anxiety, headachem n/v, slight extrapyrimdal

32
Q

Lithium SE

A

polydipsia/polyuria, blunting, decreased thyroid

33
Q

valproic acid

A

(BLACK BOX hepatic failure, pancreatitis, teratogenic) - other thrombocytopenia

34
Q

carbamazepine

A

BLACK BOX - problems in Asians, aplastic anemia, agranulocytosis, dermatological tox

CNS I (36 decks)

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