AP/AD side effects Flashcards
TCAs in general
sedation, anticholernergic, prolonged QT, weight gain
MOAis in general
hypertensive/serotonin crisis, orthostatic hypotension, sexual dyfunction, weight gain
SSRIs in general
agitation, insomnia, sexual dysfunction,
sertraline specific
nausea
paroxetine specific
sedation, bad withdrawal
citalopram specific
prolonged QT, interacts with PPI in elderly
SNRI in general
noradrenergic, nausea on start, withdrawal syndrome
venlafaxine specific
dose dependant hypertension
nefazodone specific
small risk of liver dysfunction
trazodone specific
sedation, priapism
bupropion
stimulant, dose related risk of seizures, risk of eating disorders
mirtzapine
very sedating, weight gain
paraxone/ fluoxetine can reduce effect of
makes less effective: tamoxifen, codine (any prodrugs)
fluvoxamine can increase effect of
caffiene, clozapine
SSRI/SNRI can cause bleeding with
warfarin, NSAIDS, aspirin
typical APs in general
extrapyrimidal SE, endocrine disturbances, edema and weight gain, sedation, convulsions in epileptics,
chlorpromazine specific
sedation, autonomic sx worse
thioridazine
sedation, autonomic sx worse
loxapine
higher extrapyramidal effects
molindone
higher sedation and extrapyramidal
thiothixene
high extrapyramidal effects
fluphenazone
very high high extrapyramidal effects
haldol
very high extrapyramidal effects
typical ADs interact with
increase effects of CNS depressants, reduce L-Dopa, increase anticholenergic effects of TCA
atypical APs in general
possible diabetes, weight gain, extrapyrimidal, endocrine
cloazpine
AGRANULOCYTOSIS, de novo seizures, salaivation,
risperidone/paliperadone
asthenia, drowsiness, high prolactin, most likely of 2AP to cause extrapyramidal SE
olanzapine
extrapyramidal SE, posterural hypotension, constipation and weight gain
quetapine
BLACK BOX FOR QTc, tradive dyskinesias
ziprasidone
slight QTc, weight loss, transient prolactin
ariripirazole
anxiety, headachem n/v, slight extrapyrimdal
Lithium SE
polydipsia/polyuria, blunting, decreased thyroid
valproic acid
(BLACK BOX hepatic failure, pancreatitis, teratogenic) - other thrombocytopenia
carbamazepine
BLACK BOX - problems in Asians, aplastic anemia, agranulocytosis, dermatological tox