NeuroImaging Flashcards
Be able to describe how neuroimaging technologies (specifically MRI, PET & CAT) work. Be able to list benefits and drawbacks of each technology, such as invasiveness and resolution. Be able to describe consistent neuroimaging findings for psychiatric and neurological disorders.
shows up brightest in T1
solid tissues, such as WM, Bone, Fat, GM
shows up brightest in T2
liquids, such as CSF
dye useful to distinguish old lesions from new lesions in MRI
gadolinium
why is gadolinium used to check for new lesions in MRI
does not cross blood brain barrier, so will be extruded in new bleeding lesions
advantages of FLAIR MR imaging
T2 image that suppresses CSF, can see lesions close to ventricles
lesion in T1 view of MS
hypointense lesions in Corpus callosum
lesion in T2 view of MS
hyperintense WM plaques
lesion in FLAIR view of MS
hyperintensites
imaging that can show white matter tracts
DTI
advantages of CT over MRI
cheaper, more widely available,can be used with metal in pt
disadvantages of CT
uses ionizing radiation
advantages of MR over CT
better spatial resolution, non ionizing radiation
way PET
radioactive glucose-type molecule is not metabolized, and sticks to the cell
PET shows
baseline metabolism
PET good for showing
cancer and epileptic loci
imaging findings characteristic of dementia
global reduction in gray matter volume
imaging findings characteristic of schizophrenia
no consistant abnormality, but increase in number of common abnormalities. Possibly enlarged ventricles
imaging findings characteristic of depression
POSSIBLE increase in amygdala
PET finding in depression
amygdala hypometabolism
FMRI finding in depression
subgenual cingulate hypo-response
inferior frintal hypo-response to positive images
amydgala hyper response to negative images
fMRI finding in PTSD
hyper-resoponse in right frontal and amygdala to threatening stimuli, reduced benzo binding, smaller hippocampal volumes
PET finding in OCD
hyper-metabolism of OFC, cingulate, caudate
fMRI finding in OCD
hyper-response in OFC, cingulate, and caudate to conflict tasks
fMRI imaging findings in schizophrenia
decreased DLPFC activity during executive function tasks, elevated auditory cortex activity with auditory hallucinations
