SARS Flashcards
SARS is what type of virus
coronavirus
coronavirus features
enveloped ss + RNA easily mutatable peplomers on surface- club shaped irregularly shaped 60-220nm
surface proteins on coronaviruses
spike glycoprotein
membrane glycprotein
hemagglutinin esterase
nucleocapsid phosphoprotein
spike glycoprotein
receptor binding and cell fusion
membrane glycoprotein
budding and envelop formation
hemagglutinin esterase
attachment of silic acids
nucleocapsid phosphoprotein
associates with viral RNA genome and cell cycle regulation
SARS potential drug target
3CLpro or NSP2- main protease that cleaves the polypro tin
drug blocks its action to prevent virus maturation and spread
coronavirus life cycle
- attaches to host via O-acetylated silic acid host receptor
- endocytosed
- begins protein synthesis in cytoplasm
- large polyprotein synthesized and cleaved into necessary proteins
SARS source
bats in china
SARS transmission
close contact with people via respiratory droplets OR contact with contaminated fomite and then touching eye, nose, mouth
what does SARS cause
viral pneumonia
symptoms of SARS
fever dry cough dyspnea headache hypoxemia
lab findings associated with SARS
decreased WBC increased AFT (liver damage)
cause of death in SARS
respiratory failure from alveolar damage
