Mucoactive drugs Flashcards
hypertonic saline
expectorant- hydrates PCL and decreases mucus viscosity
cough
used in CF
guaifenesin
expectorant
increases secretions and reduce viscosity
cholinergic induced cough (vagal and gastric nerves)
combined with DM
acetylcysteine
mucolytic- splits disulfide bonds between mucin monomers
anti inflammatory/anti oxidant properties to neutralize free thiol reactivity
dornase alpha
mucolytic
DNAse cleaves DNA tangles in mucus to reduce viscosity in CF
albuterol
beta agonist
bronchodilator
formoterol
beta agonist
bronchodilator
metaproternol
beta agonist
bronchodilator
pirbuterol
beta agonist
bronchodilator
salmeterol
beta agonist
bronchodilator
calfactant “factant”
pulmonary surfactant
holds alveoli open
anticholinergics
mucoregulators
ipratropium bromide
tiotropium bromide
block vagal tone for airway dilation and decreased mucus production
inhaled corticosteroids
mucoregulators
“sone”
oral corticosteroids
prednisone
omalizumab
anti-inflammatory biologic- anti IgE
mucoactive drug
changes the production, secretion, composition, and/or interactions of mucous with mucociliary epithelium
expectorants
induces cough
increase volume of secretion
mucolytics
reduce mucus viscosity
mucokinetics
increase mucus mobility
mucoregulators
control mucus secretion
mucus
network of glycosylated mucin filaments
thiol cross links
bound by non-covalent bonds
guaifenesin ADR
rare GI disturbances, dizzinness, headache, rash
nephrolithiasis (excessive use)- metabolite of drug is in stones
guaifenesin use
sinusitis
pharyngitis
bronchitis
asthma
acetylcysteine use
atelectasis
COPD
CF
bronchitis
acetylcysteine ADR
smells bad- hide in something if PO
bronchospasms if inhaled- give with beta agonist
Dornase alpha ADR
hypersensitivity- made in CHO cells
surfactant ADR
dosing- hypoxia from injecting a liquid, bradycardia
after- hyperopia, hypocapnia from rapid increase in oxygenation
hypersenitivity
macrolides
clear pseudomonas
anti inflammatory
decrease mucus secretion
