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Block 5 > Mucoactive drugs > Flashcards

Mucoactive drugs Flashcards

1
Q

hypertonic saline

A

expectorant- hydrates PCL and decreases mucus viscosity
cough
used in CF

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2
Q

guaifenesin

A

expectorant
increases secretions and reduce viscosity
cholinergic induced cough (vagal and gastric nerves)
combined with DM

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3
Q

acetylcysteine

A

mucolytic- splits disulfide bonds between mucin monomers

anti inflammatory/anti oxidant properties to neutralize free thiol reactivity

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4
Q

dornase alpha

A

mucolytic

DNAse cleaves DNA tangles in mucus to reduce viscosity in CF

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5
Q

albuterol

A

beta agonist

bronchodilator

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6
Q

formoterol

A

beta agonist

bronchodilator

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7
Q

metaproternol

A

beta agonist

bronchodilator

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8
Q

pirbuterol

A

beta agonist

bronchodilator

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9
Q

salmeterol

A

beta agonist

bronchodilator

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10
Q

calfactant “factant”

A

pulmonary surfactant

holds alveoli open

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11
Q

anticholinergics

A

mucoregulators
ipratropium bromide
tiotropium bromide
block vagal tone for airway dilation and decreased mucus production

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12
Q

inhaled corticosteroids

A

mucoregulators

“sone”

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13
Q

oral corticosteroids

A

prednisone

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14
Q

omalizumab

A

anti-inflammatory biologic- anti IgE

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15
Q

mucoactive drug

A

changes the production, secretion, composition, and/or interactions of mucous with mucociliary epithelium

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16
Q

expectorants

A

induces cough

increase volume of secretion

17
Q

mucolytics

A

reduce mucus viscosity

18
Q

mucokinetics

A

increase mucus mobility

19
Q

mucoregulators

A

control mucus secretion

20
Q

mucus

A

network of glycosylated mucin filaments
thiol cross links
bound by non-covalent bonds

21
Q

guaifenesin ADR

A

rare GI disturbances, dizzinness, headache, rash

nephrolithiasis (excessive use)- metabolite of drug is in stones

22
Q

guaifenesin use

A

sinusitis
pharyngitis
bronchitis
asthma

23
Q

acetylcysteine use

A

atelectasis
COPD
CF
bronchitis

24
Q

acetylcysteine ADR

A

smells bad- hide in something if PO

bronchospasms if inhaled- give with beta agonist

25
Q

Dornase alpha ADR

A

hypersensitivity- made in CHO cells

26
Q

surfactant ADR

A

dosing- hypoxia from injecting a liquid, bradycardia
after- hyperopia, hypocapnia from rapid increase in oxygenation
hypersenitivity

27
Q

macrolides

A

clear pseudomonas
anti inflammatory
decrease mucus secretion

Block 5 (27 decks)

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