Micro- Anti TB Therapy Flashcards
1
Q
4 reasons for combo therapy
A
subpopulations are resistant
different environments
different MOAs are better
different bug replication rate
2
Q
first line TB drugs
A
isoniazid
rifampin
pyrazinamide
ethambutol OR streptomycin
3
Q
isoniazid
A
PO or IV cidal give pyridoxine hepatotoxicity neurotoxicity
4
Q
rifampin
A
PO, IM cidal hepatotoxicity drug interactions red secretions
5
Q
pyrazinamide
A
PO cidal shortens treatment hepatotoxicity hyperuricemia
6
Q
ethambutol
A
PO
static
requires dose reduction in renal insufficiency
optic neuritis
7
Q
streptomycin
A
IM cidal dose reduction in renal insufficiency ototoxicity nephrotoxic
8
Q
drugs for cavities
A
iso
rif
ethambutol
9
Q
drugs for extracellular
A
iso rif ethambutol strepto quinolones
10
Q
drugs for intracellular
A
iso
rif
quinolones
11
Q
which is better ethambutol or streptomycin and why
A
eth- less toxic and given PO
12
Q
how long do you treat active TB
A
6 months or 3 months after negative cultures
13
Q
MDR-TB
A
resistant to iso and rif
14
Q
XDR-TB
A
resistant to iso and rif AND quinolones and an injectable (amikacin)
15
Q
second line drugs (7)
A
quinolones aminoglycosides para-amino salicylic acid cycloserine ethionamide bedaquiline linezolid
