Lung 2

Question 1

diffuse interstitial/restrictive disease

Answer 1

diffuse, chronic involvement of pulmonary interstitum reducing FEV1 and FVC

Question 2

wheezing in restrictive disease?

Answer 2

NO- only in obstruction

no obstruction in restrictive

Question 3

cause of diffuse interstitial disease

Answer 3

inhalation of agents that cause inflammation and lead to permanent fibrosis

Question 4

Fibrosing disorders

Answer 4

idiopathic pulmonary fibrosis/UIP
nonspecific interstitial pneumonia
cytogenic organizing pneumonia

Question 5

pathological pattern for IPF and other associated conditions

Answer 5

usual interstitial pneumonia (UIP)

Question 6

diagnosis of exclusion

Answer 6

idiopathic pulmonary fibrosis (IPF)/ UIP

NSIP

Question 7

main cause IPF

Answer 7

smoking

Question 8

genetic mutations associated with IPF

Answer 8

TERT and TERC- telomerase

increased MUC5B secretion

Question 9

pathological markers for UIP/IPF

Answer 9

honeycombing- widened septa
temporal heterogeneity
dense collagenous fibrous areas mixed with normal lung
stiff lungs

Question 10

IPF treatment

Answer 10

lung transplant

Question 11

causes of UIP

Answer 11

collagen vascular disease
drug toxicity
chronic hypersensitivity pneumonitis
asbestosis
familial idiopathic pulmonary fibrosis

Question 12

radiological findings for diffuse interstitial disease

Answer 12

small nodules
irregular lines (ground glass shadows)

Question 13

causes of NSIP

Answer 13

collagen vascular disease
hypersensitivy pneumonitis
drug induced pneumonitis
infection
immunodeficiency

Question 14

NSIP descriptors

Answer 14

cellular or fibrosing pattern
lack of temporal heterogeneity
46-55

Question 15

which is better prognosis cellular or fibrosing pattern of NSIP?

Answer 15

cellular

Question 16

IPF descriptors

Answer 16

smoker
>50y
gradual deterioration with hypoxemia, cyanosis, clubbing

Question 17

cytogenic organizing pneumonia

Answer 17

unknown cause
polypoid plugs of loose CT in alveolar ducts, alveoli, bronchioles
lack of temporal heterogeneity
no interstitial fibrosis

Question 18

lack of temporal heterogenity

Answer 18

cytogenic organizing pneumonia

NSIP

Question 19

temporal heterogenity

Answer 19

IPF/UIP

Question 20

honeycomb lung

Answer 20

IPF/UIP

asbestosis

Question 21

cryptogenic organizing pneumonia is similar to

Answer 21

**usually unknown
viral/bacterial pneumonia
inhaled toxins
collagen vascular disease
GVHD

Question 22

diseases associated with pulmonary involvement in collagen vascular disease

Answer 22

systemic sclerosis
lupus
RA
prognosis better than IPF

Question 23

pneumoconeosis

Answer 23

nonneoplastic responses to inhaled particulates from occupational exposures

Question 24

pneumoconeosis diagnosis

Answer 24

b readings- radiography
pulmonary function tests
biopsy
autopsy

Question 25

1 treatment for pneumoconeoses

Answer 25

prevention

Question 26

anthracosis

Answer 26

carbon particles along lymphatics with no fibrosis

CWP

Question 27

simple CWP

Answer 27

carbon accumulation in respiratory bronchioles with fibrosis
nodules to larger macules in upper lobes and upper zones of lower lobes along the respiratory bronchioles
little to no pulmonary dysfunction

Question 28

progressive massive fibrosis

Answer 28

large black scars with significant decrease in lung function
takes years to develop
center may be necrotic
severe CWP and sillicosis

Question 29

acute silicosis

Answer 29

accumulation of protein rich fluid in alveoli

Question 30

accelerated silicosis

Answer 30

nodular fibrosis complications in years

Question 31

preferred lob for silicosis

Answer 31

upper lobes

Question 32

which type of asbestos is worse

Answer 32

amphibole is worse than chrysotile

chrysotile is more common in US

Question 33

preferred lobe for asbestosis

Answer 33

lower

Question 34

pathological features of asbestosis

Answer 34

honeycombing
pleural plaques
asbestos bodies- fiber coated in iron