Bacterial respiratory pathogens

Question 1

which pathogen is obligate intracellular

Answer 1

chlamydia psittaci

Question 2

elementary body

Answer 2

metabolically inactive form of chlamydia psittaci

infectious phase

Question 3

reticulate body

Answer 3

intracellular, non infectious form of chlamydia psittaci

Question 4

chlamydia causes

Answer 4

parrot fever

Question 5

speed of chlamydia growth

Answer 5

slow

Question 6

major symptoms of parrot fever

Answer 6

flu like symptoms + respiratory infection

Question 7

parrot fever diagnosis

Answer 7

exposure to birds
clinical presentation
positive antibody titer for chlamydia

Question 8

treatment of parrot fever

Answer 8

tetracycline

treat 10-14 days post fever to prevent relapse

Question 9

description of Haemophilus influenzae

Answer 9

gram negative coccobacillus
grows on chocolate agar- need Hematin and NAD to grow
CO2 rich environment
encapsulated
no toxins

Question 10

speed of H influenza growth

Answer 10

fast

Question 11

risk factors for H influenzae

Answer 11

sickle cell
asplenia
HIV
antibody/complement deficient
chemo/radiation
stem cell transplant

Question 12

description of pertussis

Answer 12

gram negative coccobacillus
slow growing
fastidious
strict aerobe
releases toxins

Question 13

pertussis causes

Answer 13

whooping cough

Question 14

treatment of pertussis

Answer 14

antibiotics in stage 1

once cough starts antibiotics do not work (bug gone)

Question 15

catarrhal stage of pertussis

Answer 15

stage 1- sticks to trachea via fimbriae

URI

Question 16

paroxysmal stage of pertussis

Answer 16

severe whooping cough
toxin release
vomitting, weight loss, dehydration
possible neurological damage

Question 17

location of pertussis bugs

Answer 17

trachea- destroy epithelium

Question 18

major signs of pertussis

Answer 18

cough

leukocytosis–increased WBC because macrophages in bone marrow attacked by toxins so they can’t break them down

Question 19

toxins released by pertussis and their functions

Answer 19

pertussis toxin

adenylate cyclase toxin

Question 20

pertussis toxin

Answer 20

long range immunosuppressor
inhibits neutrophil and macrophage recruitment
blocks Gi –> increase cAMP

Question 21

adenylate cyclase toxin

Answer 21

short range immune cell suppressor
kills macrophages
local neutrophil deregulation
turns ATP into cAMP

Question 22

pertussis incubation period

Answer 22

7-10 days

Question 23

why is the acellular pertussis vaccine bad

Answer 23

Th2 response instead of Th1/Th17 response

does not stop transmission of bacterium