resp pharm

Question 1

1st generation reversible inhib of H1 receptors

use: allergy, motion sickness, sleep aid

Answer 1

diphenhydramine, dimenhydrinate, chlorpheniramine

Question 2

2nd generation reversible inhib of H1 receptors

use: allergy

Answer 2

loratadine, fexofenadine, desloratadine, cetirizine

Question 3

expectorant to thin resp secretions, no suppression of cough reflex

Answer 3

guaifenesin

Question 4

mucolytic to loosen mucus plugs in CF pt by disrupting disulfide bonds
also used as antidote for acetaminophen OD

Answer 4

N-acetylcysteine

Question 5

anti tussive (antagon at NMDA glutamate receptors), synthetic codeine analog, mild opioid effect if used in excess
mild abuse potential

Answer 5

dextromethorphan

Question 6

alpha adrenergic agonists

use: nasal decongestant, reduce hyperemia & edema & nasal congestion, open obstructed eustachian tube

Answer 6

pseudoephedrine, phenylephrine

Question 7

competitively antagon endothelin1 receptors - decr pulm vasc resistance
use: pulm HTN

Answer 7

bosentan

Question 8

PDE5 inhibitor - inhib cGMP PDE5 & prolong vasodilatory effect of NO
use: pulm HTN, ED

Answer 8

sildenafil

Question 9

prostacyclin analogs with direct vasodilatory effects on pulm & systemic arterial vasc, inhib platelet aggreg\
use: pulm HTN

Answer 9

epoprostenol, iloprost

Question 10

beta2 agonist that relaxes bronchial smooth m.

use: acute exacerbation asthma

Answer 10

albuterol

Question 11

beta2 agonists: long acting for prophyl of asthma

Answer 11

salmeterol, formoterol

Question 12

corticosteroids that inhib synth of CK’s, inactivate NF-kB - inhib production of TNFa
use: 1st line for chronic asthma

Answer 12

fluticasone, budesonide

Question 13

muscarinic antagon to prevent bronchoconstriction

use: asthma, COPD

Answer 13

ipratropium, tiotropium

Question 14

anti leukotrienes that block leukotriene receptors

use: asthma esp. ASA induced

Answer 14

montelukast, zafirlukast

Question 15

5 lipoxygenase path inhibitor blocks conversion of AA to leukotrienes
use: asthma

Answer 15

zileuton

Question 16

MoAb IgE binds unbound serum IgE to block binding to FcERI

use: allergic asthma resistant to inhaled steroids & long acting beta2 agonists

Answer 16

omalizumab

Question 17

causes bronchodilation by inhib PDE - incr cAMP d/t less cAMP hydrolysis
use: asthma

Answer 17

theophylline

Question 18

M3 agonist used in bronchial challenge test to diagnose asthma

Answer 18

methacholine