Toxins

Question 1

fugu/poorly prepared pufferfish

Answer 1

Tetrodotoxin

Question 2

binds fast VG Na+ channels in cardiac/nerve tissue - prevents depol - nausea, diarrhea, paresthesias, weakness, dizzy, loss of reflexes

Answer 2

Tetrodotoxin MOA
(tx is supportive)

Question 3

consume reef fish- barracuda, snapper, moray eel

Answer 3

Ciguatoxin

Question 4

opens Na+ channels - depolarizes - S&S confused with cholinergic poisoning (temp dysesthesia)

Answer 4

Ciguatoxin MOA

tx is supportive

Question 5

consume dark meat fish ie. bonito, mackerel, mahi-mahi, tuna which is stored at warm temps

Answer 5

scombroid poisoning

Question 6

acute onset burning of mouth, facial flushing, erythema, urticaria, pruritus, HA, anaphylaxis-like rxn
result of bacterial histidine decarboxylase converting histidine to histamine

Answer 6

scombroid MOA

tx supportively w/ anti histamines, epi if needed