G protein linked 2nd messengers & function

Question 1

alpha 1 receptors

Answer 1

sympathetic, q (G protein class)

vasoconstricts, mydriasis, raises intestinal & bladder sphincter m contraction (no pee/poop)

Question 2

alpha 2 receptors

Answer 2

sympathetic, i (G protein class)

lowers sympathetic outflow, lowers insulin, lowers lipolysis, increases platelet aggreg, lowers aq. humor production

Question 3

beta 1 receptors

Answer 3

sympathetic, s (G protein class)
raises HR & contractility & renin release
increases lipolysis

Question 4

beta 2 receptors

Answer 4

sympathetic, s (G protein class)
vasodilate, bronchodilate
increase lipolysis, insulin
lower uterine tone (tocolysis)
ciliary m. relaxation, raise aq. humor production

Question 5

M1 receptors

Answer 5

parasympathetic, q (G protein class)

CNS, enteric nervous system

Question 6

M2 receptors

Answer 6

parasympathetic, i (G protein class)

lowers HR & atrial contractility

Question 7

M3 receptors

Answer 7

parasympathetics, q (G protein class)
raises exocrine gland secretions (lacrimal, salivary, gastric acid)
increases gut peristalsis, bladder contraction (pee), bronchoconstriction, miosis
ciliary m. contraction (accomodation)

Question 8

D1 receptors

Answer 8

s (G protein class)

relaxes renal vasc smooth m. (vasodilates)

Question 9

D2 receptors

Answer 9

i (G protein class)

modulates transmitter release esp. in brain

Question 10

H1 receptors

Answer 10

q (G protein class)
increases nasal & bronchial mucus production
increases vasc perm, pruritus, pain
bronchiole constriction

Question 11

H2 receptors

Answer 11

s (G protein class)

increases gastric acid secretion

Question 12

V1 receptors

Answer 12

vasopressin receptor, q (G protein class)

vasconstriction

Question 13

V2 receptors

Answer 13

vasopressin receptor, s (G protein class)
incr water perm & reabsorpt in collecting tubules
(‘V2 found in the 2 kidneys’)