Muscarinic antagonists

Question 1

antidote given for organophosphate poisoning

competitive inhibitor

Answer 1

atropine

Question 2

regenerates AChE

given as part of antidote in organophosphate poisoning

Answer 2

pralidoxime

Question 3

cause mydriasis & cycloplegia

Answer 3

atropine, homatropine, tropicamide

Question 4

used in tx of Parkinson’s & acute dystonia

Answer 4

Benztropine

Question 5

parenteral: used pre-op to reduce airway secretions
oral: used to tx drooling, peptic ulcers

Answer 5

Glycopyrrolate

Question 6

anti spasmodics for IBS

Answer 6

Hyoscyamine, dicyclomine

Question 7

used to tx COPD, asthma

Answer 7

Ipratropium
tiotropium
‘I pray I can breathe soon’

Question 8

reduces bladder spasms & overactive bladder

Answer 8

oxybutynin, solifenacin, tolterodine

Question 9

used to tx motion sickness

Answer 9

scopolamine

Question 10

used to treat bradycardia & ophthalmic conditions…
dilates pupils, cycloplegia, lowers secretions, lowers acid secretion of stomach, less gut motility, less urgency in cystitis
SE: acute angle closure glaucoma in elderly, urinary retention in BPH, hyperthermia in infants (blocks sweating)

Answer 10

atropine